An integrated pharmacokinetics (PK) model that simultaneously describes concentrations of total antibody (Tab) and antibody-conjugated monomethyl auristatin E (acMMAE) following administration of monomethyl auristatin E (MMAE)-containing antibody-drug conjugates (ADCs) was developed based on phase I PK data with extensive sampling for two ADCs. Two linear two-compartment models that shared all ...

purpose: to report a case of recurrent keratoconus after penetrating keratoplasty (pk). patient and findings: a 31-year-old male patient who had undergone pk in his right eye for keratoconus 10 years ago presented with gradually decreased vision in the right eye. clinical, topographic, and histopathologic features of the cornea including irregular myopic astigmatism, central and paracentral cor...

Six dissociable groups exist in tetrahydrofolic acid in the range Ho -3.0 to pH 14. The assignments in tetrahydrofolic acid by titrimetric and spectrophotometric comparisons with model compounds, +uninobenzoylglutamic acid and 2-amino-6,7-dimethyl-5,6,7,8-tetrahydro-4-pteridinone, are as follows: acidic ionization of amide, pK’ 10.5; Ns, pK’ 4.82; y-carboxyl, pK’ 4.8; cr-carboxyl, pK’ 3.5; N1, ...

Pharmacokinetics and pharmacodynamics are divisions of pharmacology that study the action of the body on the drug and the action of the drug on the body, respectively. They complete dose titration studies aimed to select rational dosage regimens. The classical pharmacokinetic (PK)/pharmacodynamic (PD) studies are experimental. They are usually performed on healthy volunteers or highly selected ...

The G-vertex colored partition algebras Pk(x, G) and extended G-vertex colored partition algebras b Pk(x, G) have been recently defined in [16] and [17] respectively and they have been realized as the centralizer algebras of the groups Sn × G and Sn respectively, under the action on W ⊗k, where W = Cn|G| and C is the field of complex numbers. In this paper, we use the representation theory of t...

In the current study, we used four soybean varieties PK-1029, PK-472, NRC-7, and Hardee to examine effect of exclusion solar UV radiation on photosynthetic efficiency test possible variety-dependent sensitivity ambient (280-400 nm). Plants that were grown under filters had higher chlorophyll a b, efficiencies PSII more active reaction centers indicated substantially affected by radiation. The s...

Matrilysin activity exhibits a broad bell-shaped pH-dependence profile, with pK(a) values of 4.0 and 9.8. A maximum of five out of eight tyrosine residues in matrilysin were nitrated with tetranitromethane. On nitration of between one and five tyrosines, pK(a) at the alkaline side (pK(e2)) was shifted from 9.8 to 10.3-10.6, while that at the acidic side (pK(e1)) was not altered. The pK(e2) that...

Atherton, John G. (University of Southern California, Los Angeles), Sotiros G. Chaparas, Martha Cremer, and Irving Gordon. Mechanism of polykaryocytosis associated with noncytopathic infection by measles virus. J. Bacteriol. 90:213-219. 1965.-Infection with a measles virus variant resulted not only in formation of polykaryocytes (PK) but also in formation of multicellular immunofluorescent foci...

This thesis describes the development of a software prototype implemented in Matlab for non-linear mixed effects modelling based on stochastic differential equations (SDEs). The setup aims at modelling measurements originating from more than one individual and it represents a powerful way of modelling systems with complicated and partially unknown dynamics. The incorporation of SDEs enables the...