نتایج جستجو برای: plzf

تعداد نتایج: 453  

Journal: :Journal of immunology 2011
Hye Sook Min You Jeong Lee Yoon Kyung Jeon Eun Ji Kim Byung Hyun Kang Kyeong Cheon Jung Cheong-Hee Chang Seong Hoe Park

We have recently shown that MHC class II-dependent thymocyte-thymocyte (T-T) interaction successfully generates CD4(+) T cells (T-T CD4(+) T cells), and that T-T CD4(+) T cells expressing promyelocytic leukemia zinc finger protein (PLZF) show an innate property both in mice and humans. In this article, we report that the thymic T-T interaction is essential for the conversion of CD8(+) T cells i...

2017
Hailing Zhao Xin Li Tingting Zhao Haojun Zhang Meihua Yan Xi Dong Pengmin Chen Liang Ma Ping Li

The Chinese herbal granule Tangshen Formula (TSF) has been proven to decrease proteinuria and improve estimated glomerular filtration rate (eGFR) in diabetic kidney disease (DKD) patients. However, the underlying mechanism of TSF on treatment of diabetic nephropathy (DN) remains unclear. The present study aimed to identify the therapeutic target of TSF in diabetic renal injuries through microar...

Journal: :Journal of immunology 2017
Yeung-Hyen Kim Ajay Kumar Cheong-Hee Chang Kalyani Pyaram

Reactive oxygen species (ROS) are byproducts of aerobic metabolism and contribute to both physiological and pathological conditions as second messengers. ROS are essential for activation of T cells, but how ROS influence NKT cells is unknown. In the present study, we investigated the role of ROS in NKT cell function. We found that NKT cells, but not CD4 or CD8 T cells, have dramatically high RO...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 1998
K F Ahmad C K Engel G G Privé

The BTB domain (also known as the POZ domain) is an evolutionarily conserved protein-protein interaction motif found at the N terminus of 5-10% of C2H2-type zinc-finger transcription factors, as well as in some actin-associated proteins bearing the kelch motif. Many BTB proteins are transcriptional regulators that mediate gene expression through the control of chromatin conformation. In the hum...

Journal: :Journal of immunology 2012
Archna Sharma Qinghua Chen Trang Nguyen Qing Yu Jyoti Misra Sen

Innate memory-like CD8 thymocytes develop and acquire effector function during maturation in the absence of encounter with Ags. In this study, we demonstrate that enhanced function of transcription factors T cell factor (TCF)-1 and β-catenin regulate the frequency of promyelocytic leukemia zinc finger (PLZF)-expressing, IL-4-producing thymocytes that promote the generation of eomesodermin-expre...

2000
Eduardo M. Rego Li-Zhen He Raymond P. Warrell Pier Paolo Pandolfi

Acute promyelocytic leukemia (APL) is associated with chromosomal translocations always involving the RARa gene, which variably fuses to one of several distinct loci, including PML or PLZF (X genes) in t(15;17) or t(11;17), respectively. APL in patients harboring t(15;17) responds well to retinoic acid (RA) treatment and chemotherapy, whereas t(11;17) APL responds poorly to both treatments, thu...

2016
František Liška Renata Peterková Miroslav Peterka Vladimír Landa Václav Zídek Petr Mlejnek Jan Šilhavý Miroslava Šimáková Vladimír Křen Colby G. Starker Daniel F. Voytas Zsuzsanna Izsvák Michal Pravenec

Recently, it has been found that spontaneous mutation Lx (polydactyly-luxate syndrome) in the rat is determined by deletion of a conserved intronic sequence of the Plzf (Promyelocytic leukemia zinc finger protein) gene. In addition, Plzf is a prominent candidate gene for quantitative trait loci (QTLs) associated with cardiac hypertrophy and fibrosis in the spontaneously hypertensive rat (SHR). ...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2015
Michael G Constantinides Herman Gudjonson Benjamin D McDonald Isabel E Ishizuka Philip A Verhoef Aaron R Dinner Albert Bendelac

Among the variety of tissue-resident NK-like populations recently distinguished from recirculating classical NK (cNK) cells, liver innate lymphoid cells (ILC) type 1 (ILC1s) have been shown to represent a distinct lineage that originates from a novel promyelocytic leukaemia zinc finger (PLZF)-expressing ILC precursor (ILCP) strictly committed to the ILC1, ILC2, and ILC3 lineages. Here, using PL...

Journal: :Nature Genetics 2004

Journal: :Cancer research 2013
Arnab Ghosh Amanda M Holland Yildirim Dogan Nury L Yim Uttam K Rao Lauren F Young Mallory L West Natalie V Singer Hae Lee Il-Kang Na Jennifer J Tsai Robert R Jenq Olaf Penack Alan M Hanash Cecilia Lezcano George F Murphy Chen Liu Michel Sadelain Martin G Sauer Derek Sant'angelo Marcel R M van den Brink

Efforts to limit GVHD mediated by alloreactive donor T cells after allogeneic bone marrow transplantation are limited by a concomitant decrease in graft-versus-tumor (GVT) activity and increased possibilities of tumor relapse. Using a novel approach, we adoptively transferred conventional T cells expressing the transcription factor promyelocytic leukemia zinc finger (PLZF), which confers effect...

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