Global Alliance for Vaccines and Immunization (GAVI, the Vaccine Alliance) is an international organization built through public-private partnership. GAVI has supported more than 200 vaccine introductions in the last 5 years by financing major proportion of costs of vaccine to 73 low-income countries using a co-financing model. GAVI has worked in close co-ordination with Global Polio Eradicatio...

Since the World Health Assembly endorsed a plan to completely eradicate polio in 1988, the large‑scale use of the attenuated oral poliovirus vaccine (OPV) has drastically decreased the number of polio cases. However, the OPV vaccine brings rare but serious adverse consequences, especially in the Type 2 vaccine strains. Most vaccine‑associated paralytic poliomyelitis (VAPP) outbreaks are associa...

As the goal to eradicate wild polio virus (WPV) is approached, outbreaks associated with vaccine derived polioviruses (VDPV) with neurovirulent properties have emerged. The relevance for the spread of infection by nonparalytic cVDPV cases, with mutations associated with neurovirulence, is discussed with reference to the molecular analysis of a VDPV isolated from a Jamaican child who presented w...

Should polio be eradicated worldwide, countries must decide whether to continue to vaccinate with the live-attenuated vaccine, to continue to vaccinate with the alternative, killed vaccine, or to cease vaccinating. To reap a dividend from polio eradication, countries must choose the last option, but vaccination cessation entails interdependent risks as well as rewards. This article models the p...

India's success in eliminating wild polioviruses (WPVs) has been acclaimed globally. Since the last case on January 13, 2011 success has been sustained for two years. By early 2014 India could be certified free of WPV transmission, if no indigenous transmission occurs, the chances of which is considered zero. Until early 1990s India was hyperendemic for polio, with an average of 500 to 1000 chi...

Global importance of the health condition today: today, polio is on the verge of being erased from the globe. as recently as 988, 25 countries were endemic for polio, with an estimated 350,000 cases. through the first half of 2006, just four countries were reported endemic for polio, and fewer than 700 cases were reported worldwide. this dramatic reduction is the result of massive oral polio va...

In a simple study into the control of polio in the Third World a town was divided into 16 zones and pulses or oral polio vaccine given at one station in each zone, after extensive publicity about the campaign. Some 62% of children received three doses of the vaccine and the incidence of polio fell dramatically over the study period. It is suggested that this method is applicable to similar comm...

The WHO European Region has been declared polio-free since 2002. By 2010, inactivated polio vaccine (IPV) was the only polio vaccine in use in the EU/EEA for the primary vaccination of children. A systematic review of the literature on polio seroprevalence studies, complemented by the analysis of available vaccine coverage data, has been carried out with the aim of assessing the level of protec...