Colorectal cancer is the fourth most frequently diagnosed cancer and the second leading cause of cancer death. About 96,830 new cases of colon cancer and approximately 40,000 cases of rectal cancer will occur and 50,310 people will die of colon and rectal cancer combined[1]. The long term survival rate of colon cancer patients treated by conventional modalities such as surgery, radiation, and c...

Advances in nanotechnology have led to the design of multifunctional nanoparticles capable of cellular imaging, targeted drug delivery, and diagnostics for early cancer detection. We synthesized poly(lactic-co-glycolic acid) nanoparticles encapsulating a model radiosensitizing drug docetaxel accomplishing localized in situ delivery of the sensitizer to the tumor site. The synthesized nanopartic...

Although approved by the U.S. Food and Drug Administration, enfuvirtide is rarely used in combination antiretroviral therapies (cART) to treat HIV-1 infection, primarily because of its intense dosing schedule that requires twice-daily subcutaneous injection. Here, we describe the development of enfuvirtide-loaded, degradable poly(lactic-co-glycolic) acid microparticles that provide linear in vi...

A hierarchical support vector regression (SVR) model (HSVRM) was employed to correlate the compositions and mechanical properties of bicomponent stents composed of poly(lactic-co-glycolic acid) (PGLA) film and poly(glycolic acid) (PGA) fibers for urethral repair for the first time. PGLA film and PGA fibers could provide ureteral stents with good compressive and tensile properties, respectively....

Continuous polysaccharide fibers and nonwovens—based on cellulose, hydroxypropyl chitosan, or alginate—containing biopolymeric microcapsules (MC) mesoporous silica nanoparticles (MSN) are prepared using a wet-spinning solution blowing technique. The MCs homogeneously distributed in the fiber matrices whereas MSNs form discrete micron-sized aggregates as demonstrated scanning electron-, fluoresc...

  Objective: In dental treatments, use of carriers for targeted antibiotic delivery would be optimal to efficiently decrease microbial count. In this study, gentamicin was loaded into polylactic co-glycolic acid (PLGA) microspheres and its release pattern was evaluated for 20 days.   Methods: In this experimental study, PLGA microspheres loaded with gentamycin were produced by the W/O/W method....