Polyamidoamine (PAMAM) dendrimers have previously been demonstrated to elicit systematically variable cyto- and eco-toxic responses, promising as the basis for structure-activity relationships governing nanotoxicological responses. In this study, increased production of intracellular reactive oxygen species (ROS), genotoxicity and apoptosis due to in vitro exposure of fish hepatocellular carcin...

Surface immobilized polyamidoamine (PAMAM) dendrimer templated Pt nanoparticles were employed as precursors to heterogeneous catalysts. CO oxidation catalysis and in situ infrared spectroscopy were used to evaluate conditions for dendrimer removal. Infrared spectroscopy showed that PAMAM dendrimer amide bonds begin decomposing at temperatures as low as 75 degrees C. Although the amide stretches...

The DNA microarray-based analysis of single nucleotide polymorphisms (SNPs) is important for the correlation of genetic variations and individual phenotypes, and for locating disease-causing genes. To facilitate the development of surfaces suitable for immobilization of oligonucleotides, we report here a novel method for the surface immobilization of DNA using pre-fabricated polyamidoamine (PAM...

Cationic polyamidoamine (PAMAM) dendrimers are branch-like spherical polymers being investigated for a variety of applications in nanomedicine including nucleic acid drug delivery. Emerging evidence suggests they exhibit intrinsic biological and toxicological effects but little is known of their interactions with signal transduction pathways. We previously showed that the activated (fragmented)...

One of the most pressing global concerns is how to provide a clean environment for future generations given exacerbation urban, agricultural, industrial, and economic activities due escalating size population. A polyamidoamine (PAMAM) dendrimer peripherally modified with 4-N,N?-dimethylethylenediamine-1,8-naphthalmide as chromophore was synthesized utilized capture hazardous heavy metal ions. T...

Cyclodextrin (CyD)-based nanoparticles and polyamidoamine (PAMAM) starburst dendrimers (dendrimers) are used as novel carriers for DNA and RNA. Recently, small interfering RNA (siRNA) complex with β-CyD-containing polycations (CDP) having adamantine-PEG or adamantine-PEG-transferrin underwent a phase I study for treatment of solid tumors. Multifunctional dendrimers can be used for a wide range ...

Dendrimers have been widely used as nanostructured carriers for guest species in a variety of applications in medicine, catalysis, and environmental remediation. Theory and simulation methods are an important complement to experimental approaches that are designed to develop a fundamental understanding about how dendrimers interact with guest molecules. This review focuses on computational stud...

introduction: arsenic is known as a carcinogenic compound in drinking water . it can cause acute and chronic effects on human health. in this study, the effect of polyamidoamine dendrimer generation 3(pamam g3) as adsorbents for removal of arsenic (v) from aqueous solutions was evaluated.     methods: adsorption experiment was studied in batch system and the effect of different variables like p...

Dendrimers are a relatively new class of polymer, with well-defined molecular structures. They are synthesized from a polyfunctional core by adding branched monomers that react with the functional groups of the core, in turn leaving end groups that can react again. This results in a large number of reactive terminal groups that increases after each cycle or " generation ". The structure of a gi...