Culture-dependent and culture-independent approaches were used to determine the relationship between the dehalogenase gene pool in bacteria enriched and isolated on 2,2-dichloropropionic acid (22DCPA) and the environmental metagene pool (the collective gene pool of both the culturable and uncultured microbes) from which they were isolated. The dehalogenases in the pure-cultures isolates, which ...

The adsorption of viruses from aqueous solution is frequently performed to detect viruses. Charged filtration materials capture via electrostatic interactions, but lack the specificity biological virus-binding substances like heparin. Herein, we present three methods immobilize heparin-mimicking, polymers a filter material. Two mussel-inspired approaches are used, based on dopamine or dendritic...

The ionophore 1,4,7,10,13-penta(n-octyl)-1,4,7,10,13-pentaazacyclopentadecane (L) was used for the development of miniaturised perchlorate-selective electrodes in thickfilm technology. Different PVC membranes containing L and the plasticizers o-nitrophenyl octyl ether (NPOE), dibutyl phthalate (DBP), bis(2-ethylhexyl)sebacate (DOS) and dibutyl sebacate (DBS) were prepared and placed on a graphi...

The destruction of articular cartilage is a critical feature in joint diseases. An approach to selectively target the damaged tissue is promising for the development of diagnostic and therapeutic agents. We herein present the interaction of dendritic polyglycerol (dPG) anions with native and inflamed cartilage. Confocal laser scanning microscopy revealed the inert character of dPG and low funct...

BACKGROUND Polyglycerol is an attractive hydrophilic building block of amphiphilic copolymers for biomedical and pharmaceutical applications due to its biocompatibility, facile chemical modification, and anti-fouling activity. Herein we introduce theranostic nanoemulsions incorporating anti-cancer therapeutic and contrast agents using linear polyglycerol-poly(ε-caprolactone) diblock copolymers ...

In this study, dendritic polyglycerol sulfate (dPGS) is evaluated as a delivery platform for the anticancer, tubulin-binding drug paclitaxel (PTX). The conjugation of PTX to dPGS is conducted via a labile ester linkage. A non-sulfated dendritic polyglycerol (dPG) is used as a control, and the labeling with an indocarbocyanine dye (ICC) renders multifunctional conjugates that can be monitored by...

The role of phospholipid in the uridine diphosphate-galactose :lipopolysaccharide galactosyltransferase reaction has been studied in extracts of Salmonella typhimurium by utilizing synthetic and natural phospholipids and phospholipids altered by venom digestion, alkaline hydrolysis, and catalytic hydrogenation. Activity was seen with derivatives of phosphatidic acid containing two unsaturated o...