نتایج جستجو برای: polymersome
تعداد نتایج: 167 فیلتر نتایج به سال:
Vesicles were made from amphiphilic diblock copolymers and characterized by micromanipulation. The average molecular weight of the specific polymer studied, polyethyleneoxide-polyethylethylene (EO40-EE37), is several times greater than that of typical phospholipids in natural membranes. Both the membrane bending and area expansion moduli of electroformed polymersomes (polymer-based liposomes) f...
Giant polymersomes are versatile and stable biomimetic compartments that ideal for building cell-like systems. However, the transport of hydrophilic molecules across membrane, which controls function systems, is limited by low permeability polymeric bilayers. Therefore, mechanisms to control necessary create functional Here, we describe design giant equipped with spiropyran-based modulators. Ph...
The encapsulation of chloroperoxidase from Caldariomyces fumago (CPO) in block copolymer polymersomes is reported. Fluorescence and electron microscopy show that when the encapsulating conditions favour self-assembly of the block copolymer, the enzyme is incorporated with concentrations that are 50 times higher than the enzyme concentration before encapsulation. The oxidation of two substrates ...
Vesicles prepared in water from a series of diblock copolymers “polymersomes” are physically characterized and compared to lipid vesicles. With increasing molecular weight M̄n, the hydrophobic core thickness d for the self-assembled bilayers of poly(ethylene oxide)-polybutadiene (PEO-PBD) increases up to ≃20 nm considerably greater than any previously studied lipid system. The mechanical respons...
Polymersome nanoparticles (PMs) are attractive candidates for spatio-temporal controlled delivery of therapeutic agents. Although many studies have addressed cellular uptake of solid nanoparticles, there is very little data available on intracellular release of molecules encapsulated in membranous carriers, such as polymersomes. Here, we addressed this by developing a quantitative assay based o...
BACKGROUND Newborns display distinct immune responses, leaving them vulnerable to infections and impairing immunization. Targeting newborn dendritic cells (DCs), which integrate vaccine signals into adaptive immune responses, might enable development of age-specific vaccine formulations to overcome suboptimal immunization. OBJECTIVE Small-molecule imidazoquinoline Toll-like receptor (TLR) 8 a...
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