Poor water solubility for many drugs and drug candidates remains a major obstacle to their development and clinical application. Conventional formulations to improve solubility suffer from low bioavailability and poor pharmacokinetics, with some carriers rendering systemic toxicities (e.g. Cremophor(®) EL). In this review, several major nanonization techniques that seek to overcome these limita...

Silica aerogels are porous and extremely lightweight nano-materials shows interesting properties. These materials, because of biocompatibility, non-harmful to the body and special physical characteristics such as large surface area and low density have great potential for use in a drug delivery system (DDS). The focus of this study is the evaluation of the effects of silica aerogels on improvin...

Silica aerogels are porous and extremely lightweight nano-materials shows interesting properties. These materials, because of biocompatibility, non-harmful to the body and special physical characteristics such as large surface area and low density have great potential for use in a drug delivery system (DDS). The focus of this study is the evaluation of the effects of silica aerogels on improvin...

Solid dispersions of a poorly water-soluble drug piroxicam in polyvinylpyrrolidone (PVP) were prepared by precipitation with compressed antisolvent (PCA) and spray drying techniques. Physicochemical properties of the products and drug-polymer interactions were characterized by powder X-ray diffraction, Fourier transform infrared spectroscopy, and differential scanning calorimetry, etc. Piroxica...

Proniosomal drug delivery system is a stable provesicular in nanotechnology to overcome the drawbacks associated with other vesicular systems. These are water-soluble pro-vesicular carriers coated non-ionic surfactant which on hydration give niosomes. The encapsulated and shows systemic targeted of poorly soluble drugs increased bioavailability decreased side effects. Here we have covered chara...

Masatoshi Nakatsuji, Haruka Inoue, Masaki Kohno, Mayu Saito, Syogo Tsuge, Shota Shimizu, Osamu Ishibashi Osaka Prefecture University, Graduate School of Life and Environmental Sciences 1-1 Gakuen-cho, Nakaku, Sakai, Osaka 599-8531, Japan [email protected]; [email protected]; [email protected]; [email protected]; [email protected]; sv...