Alzheimer’s disease (AD) is a neurodegenerative condition affecting millions of individuals worldwide and is a major source of mortality in elderly populations. While it is well established that there is a strong genetic basis for the disease, the epigenetic mechanism underlying the disease is largely unknown. The main purpose of this thesis is to understand the alteration of epigenetic modific...

OBJECTIVES Changes in air temperature and its relation to ambulance transports due to heat stroke in all 47 prefectures, in Japan were evaluated. METHODS Data on air temperature were obtained from the Japanese Meteorological Agency. Data on ambulance transports due to heat stroke was directly obtained from the Fire and Disaster Management Agency, Japan. We also used the number of deaths due t...

The science of demography focuses on the drivers of population dynamics: fertility, mortality, and migration. Demography is inherently interdisciplinary and draws on theory from a range of social sciences, including sociology, economics, and anthropology. The demographers’ approach to fertility research at a given time is grounded in the contemporaneous fertility trends and fertility-related te...

Genome-wide association studies (GWAS) have become popular as an approach for the identification of large numbers of phenotype-associated variants. However, differences in genetic architecture and environmental factors mean that the effect of variants can vary across populations. Understanding population genetic diversity is valuable for the investigation of possible population specific and ind...

Editorial – Chinese population challenges: fewer girls, more old people • A rapid slowdown in population growth p. 1 • The proportion of over-65s should double in the next 25 years p. 2 • More boys than girls p.3 • From the threat of growth... to the problem of ageing p. 4 C N TE N TS duction. There were fewer births in those years and mortality was exceptionally high. After a return to normal ...

Islam has a general principle of increase in population. But the Muslims are equally obliged to take care of health, education and the provisions etc. for their offspring and wives in the best possible way. The Muslims would have to regulate and manage the number of children, if any situation affects their duties regarding their wives or children. Islam accomplishes permissibility of temporary ...

This pilot study compared the perceptions of beauty among Chinese women who were exchange students in the United States with Chinese women who were students in their homeland. We interviewed 19 women in China and 19 women in the United States to determine differences in responses. In accordance with the sociocultural approach and the social comparison approach, we expected Chinese women in the ...

The identification of dog hair through mtDNA analysis has become increasingly important in the last 15 years, as it can provide associative evidence connecting victims and suspects. The evidential value of an mtDNA match between dog hair and its potential donor is determined by the random match probability of the haplotype. This probability is based on the haplotype's population frequency estim...

INTRODUCTION Making change towards child and family-based and coordinated services is critical to improve quality, outcomes and value. The Let's Talk about Children (LTC) approach, which consists of brief psychoeducational discussions with parents of kindergarten-aged and school-aged children, has been launched as a municipality-specific programme in the Council of Oulu Region. The aim of this ...

In recent years it has emerged that structural variants have a substantial impact on genomic variation. Inversion polymorphisms represent a significant class of structural variant, and despite the challenges in their detection, data on inversions in the human genome are increasing rapidly. Statistical methods for inferring parameters such as the recombination rate and the selection coefficient ...