The transport behavior of toluene and n-hexane in gamma-alumina membranes with different pore diameters was studied. It was shown that the permeability of water-lean hexane and toluene is in agreement with Darcy's law down to membrane pore diameters of 3.5 nm. The presence of molar water fractions of 5-8 x 10(-4) in these solvents led to a permeability decrease of the gamma-alumina layer by a f...

The Na+ channel is the primary target of anticonvulsants carbamazepine, phenytoin, and lamotrigine. These drugs modify Na+ channel gating as they have much higher binding affinity to the inactivated state than to the resting state of the channel. It has been proposed that these drugs bind to the Na+ channel pore with a common diphenyl structural motif. Diclofenac is a widely prescribed anti-inf...

Progressive conversion/shrinking core (PC-SC) models of constant-size cylinders were exploited to interpret the decarburization reactions of MgO-C-Si bricks heated up under blown air. Chemical adsorption/solid (or pore) diffusion mechanisms governed the reaction rate. With 5% silicon, chemical adsorption vanished at 1000 and 1100°C. The oxidation rate lowered then with temperature. This was due...

Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels are activated by membrane hyperpolarization that creates time-dependent, inward rectifying currents, gated by the movement of the intrinsic voltage sensor S4. However, inward rectification of the HCN currents is not only observed in the time-dependent HCN currents, but also in the instantaneous HCN tail currents. Inward rectific...

The gas slippage phenomenon under dry conditions has been investigated extensively both numerically and experimentally. However, very limited research focused on behavior wet conditions. Unlike conventional formation, the influence of water transport process cannot be neglected in tight formations due to comparable amount thin film attached along rock surface. It is found experimentally that fa...

[1] We analyze the streamflow response of Sespe Creek, CA, to several large earthquakes. We find that flow increased after three earthquakes, and that the observed changes in flow have the same character. Both those earthquakes that induced static extension and those that induced static contraction cause flow to increase; streamflow thus appears to respond to dynamic strain. We find that all po...

It is now recognized that polyvalent organic cations, such as polyamines, can act as endogenous modifiers of ion-channel gating, properties which were previously assumed to be entirely intrinsic to the channel proteins. All cells possess myriad different ion channels, which span their plasma membranes. These proteins are usually made up of four or five subunits, which together form an ion-perme...