The acid-sensitive ion channels (ASICs) are a family of voltage-insensitive sodium channels activated by external protons. A previous study proposed that the mechanism underlying activation of ASIC consists of the removal of a Ca2+ ion from the channel pore (Immke and McCleskey, 2003). In this work we have revisited this issue by examining single channel recordings of ASIC1 from toadfi sh (fASI...

Bone tissue engineering has been increasingly studied as an alternative approach to bone defect reconstruction. In this approach, new bone cells are stimulated to grow and heal the defect with the aid of a scaffold that serves as a medium for bone cell formation and growth. Scaffolds made of metallic materials have preferably been chosen for bone tissue engineering applications where load-beari...

Native cellular fluorescence (NCF) represents the innate capacity of tissues to absorb and emit light of specified wavelengths. Recent advances in optical engineering and computer technology have provided the, opportunity to measure NCF characteristics of various tissues in vivo. This report will briefly review the current status of NCF analysis of various neoplastic tissues. The status of inve...

The acid-sensitive ion channels (ASICs) are a family of voltage-insensitive sodium channels activated by external protons. A previous study proposed that the mechanism underlying activation of ASIC consists of the removal of a Ca2+ ion from the channel pore (Immke and McCleskey, 2003). In this work we have revisited this issue by examining single channel recordings of ASIC1 from toadfish (fASIC...

Porous ceramics composite was prepared with mixed powders (Al, TiO2 and B2O3) by SHS (Self-propagating High-temperature Synthesis) method. The effects of the particle size of aluminum power, the additives of SiC and the compacting pressure on the product properties and the pore size, as well as the combustion process in the Al2O3-TiB2 system were researched. The effects of all factors on proper...

The objective of this work was design, characterization, and optimization of controlled drug delivery system containing antibiotic drug/s. Osmotic drug delivery system was chosen as controlled drug delivery system. The porous osmotic pump tablets were designed using Plackett-Burman and Box-Behnken factorial design to find out the best formulation. For screening of three categories of polymers, ...

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Clinical Software Engineering, GE Medical Systems, Hungary [1] Computer Vision, Graphics and Pattern Recognition Group, University of Mannheim, Germany [2] Corporate Technology PS 9, Siemens AG, Munich, Germany Department of Computer Science, The Graduate Center, City University of New York, USA [3] Department of Matematics and Informatics, University of Siena, Italy [4] Department of Nuclear M...