BACKGROUND AND PURPOSE Hemodynamic insult by bilateral common carotid artery ligation has been shown to induce aneurysmal remodeling at the basilar terminus in a rabbit model. To characterize critical hemodynamics that initiate this remodeling, we applied a novel hemodynamics-histology comapping technique. METHODS Eight rabbits received bilateral common carotid artery ligation to increase bas...

Abstract The critical size of bone defects resulting from disease or fractures is a medical problem, usually unable to repair spontaneously by the body's healing mechanisms. Bioceramics are being used for tissue regeneration stimulate growth cells and guide osseous remodeling. three most common types bioceramics in engineering (hydroxyapatite, bioactive glass, tricalcium phosphate) were selecte...

BACKGROUND AND PURPOSE Distal forearm fractures in children have excellent remodeling potential. The current literature states that 15° is the maximum acceptable angulation limit, though studies focusing on remodeling capacity above this value are lacking. We present data on the remodeling process in children with distal radius malunions with an angulation of ≥ 15°. PATIENTS AND METHODS Retro...

airway remodelling is characterized by the thickening and reorganization of the airways seen in mustard  lung patients. mustard lung is the  general description  for  the  chronic obstructive  pulmonary  disease induced  by  sulfur  mustard(sm). pulmonary  disease was diagnosed as the most important  disorder in individuals that had been exposed to sulfur mustard. sulfur mustard is a chemical w...

OBJECTIVE Genetic background largely contributes to the complexity of metabolic responses and dysfunctions. Induction of brown adipose features in white fat, known as brown remodeling, has been appreciated as a promising strategy to offset the positive energy balance in obesity and further to improve metabolism. Here we address the effects of genetic background on this process. METHODS We inv...

B.I. Jugdutt and N.S. Dhalla (eds.), Cardiac Remodeling: Molecular Mechanisms, Advances in Biochemistry in Health and Disease 5, DOI 10.1007/978-1-4614-5930-9_2, © Springer Science+Business Media New York 2013 Abstract The potassium channel is a major target of remodeling in cardiac hypertrophy. To maintain physiological cardiac function in the face of increased workloads, hypertrophied cardiac...

Height is reported to be inversely associated with cardiovascular disease. And platelets play an important role in vascular remodeling by supporting CD34-positive cells. To clarify the association between height and platelet, we conducted a cross-sectional study of 219 elderly Japanese men. Since hemoglobin concentration is influenced by vascular remodeling activity, an analysis stratified by h...

Background Global left ventricular (LV) remodeling after myocardial infarction frequently occurs. Late Gadolinium Enhancement (LGE) CMR allows imaging of focal myocardial scar with areas remote from scar having no hyperenhancement. Myocardial T1 mapping allows quantification of interstitial fibrosis and may be a surrogate for LV remodeling. We sought to determine if there were T1 abnormalities ...