Cerebral vasospasm considered to be a serious cause of morbidity and mortality following subarachnoid haemorrhage (SAH).Despite several available therapeutic options, current protocols do not prevent major consequences of vasospasm. Inflammation is believed to play an important role in post-haemorrhagic vasospasm. Meloxicam is a non-steroidal anti-inflammatory drug. The aim of this study was to...

BACKGROUND AND PURPOSE We examined effects of isoflurane, volatile anesthetics, on blood-brain barrier disruption in the endovascular perforation model of subarachnoid hemorrhage (SAH) in mice. METHODS Animals were assigned to sham-operated, SAH+vehicle-air, SAH+1%, or 2% isoflurane groups. Neurobehavioral function, brain water content, Evans blue dye extravasation, and Western blotting for s...

Apolipoprotein E (Apoe) genetic polymorphisms have been implicated in the long term outcome of subarachnoid haemorrhage (SAH), but little is known about the effect of Apoe on the early brain injury (EBI) after SAH. This study investigated the potential role of APOE in EBI post-SAH. Multiple techniques were used to determine the early BBB disruption in EBI post-SAH in a murine model using wild-t...

We present a case of angiographically confirmed transection of the cisternal segment of the anterior choroidal artery (AChA) associated with a severe head trauma in a 15-year old boy. The initial brain computed tomography scan revealed a diffuse subarachnoid hemorrhage (SAH) and pneumocephalus with multiple skull fractures. Subsequent cerebral angiography clearly demonstrated a complete transec...

objective: the aim of this study is to evaluate the effectiveness of the metacognitive model in treating post-traumatic stress disorder. method: in a single-subject experimental trial of multiple baseline type, the treatment process was carried out on an 18-year-old male subject. the patient satisfied the dsm-iv criteria for ptsd and was assessed for pre-duration and post treatment. the scales ...

post-traumatic stress disorder (ptsd) is a disorder which might occur in subjects after experiencing a traumatic life event. the underlying etiology of this disorder is still unknown but malfunction of the brain’s anxiety network is discussed. therefore, neuroscience research might give new insights about the neurobiological mechanisms of ptsd. the talk will give a systematic overview about the...

various psychotherapies for post-traumatic stress disorder and disturbances associated with it are used. the purpose of this review was to introduce of traditional and modern psychotherapy in the treatment of post-traumatic stress disorder. the data was collected by searching of online databases, english articles selected from science direct, pubmed, proquest, and persian articles from medlib, ...

introduction:this study examined the effects of administration of subcutaneous β-estradiol on ptsd-like symptoms (the enhanced conditioned fear response, cfr) that induced by a single-prolonged stress (sps) and shock in rats. adult male wistar rats were exposed to sps procedure: restraint for 2 h, forced swim for 20 min, and ether anesthesia. then the rats were placed in fear conditioning syste...

following a personal, community or national crisis or disaster there is a need to provide some form of early intervention and crisis support. the essential components of successful early interventions include planning, education, training and support for those affected. the goal of all early interventions should be to maximize the likelihood of a positive mental health outcome using the person’...