نتایج جستجو برای: postsynaptic blocker

تعداد نتایج: 33982  

Journal: :Journal of neurophysiology 2006
Weifeng Song Siriporn C Chattipakorn Lori L McMahon

An inhibitory role for strychnine-sensitive glycine-gated chloride channels (GlyRs) in mature hippocampus is beginning to be appreciated. We have reported previously that CA1 pyramidal cells and GABAergic interneurons recorded in 3- to 4-wk-old rat hippocampal slices express functional GlyRs, dispelling previous misconceptions that GlyR expression ceases in early development. However, the effec...

Journal: :American journal of physiology. Heart and circulatory physiology 1999
Abdallah Hayar Patrice G Guyenet

The rostral ventrolateral medulla (RVLM) controls sympathetic tone via excitatory bulbospinal neurons. It is also the main target of α2-adrenoceptor (α2-AR) agonists used for treatment of hypertension. In this study, we examined the synaptic mechanisms by which α2-AR agonists may inhibit the activity of RVLM bulbospinal neurons. We recorded selectively from RVLM bulbospinal neurons in brain ste...

1999
ABDALLAH HAYAR Patrice G. Guyenet

Hayar, Abdallah, and Patrice G. Guyenet. a2-Adrenoceptor-mediated presynaptic inhibition in bulbospinal neurons of rostral ventrolateral medulla. Am. J. Physiol. 277 (Heart Circ. Physiol. 46): H1069–H1080, 1999.—The rostral ventrolateral medulla (RVLM) controls sympathetic tone via excitatory bulbospinal neurons. It is also the main target of a2-adrenoceptor (a2-AR) agonists used for treatment ...

2003
PETER H. HARTLINE ALAN R. ADOLPH

We investigated the action of LSD at the putative indoleaminergic lateral inhibitory synapse in the lateral eye of Limulus polyphemus . We recorded extracellular and intracellular voltage responses from eccentric cells while producing inhibition either by light or by antidromic stimulation of the optic nerve in the presence of LSD, serotonin (5-HT), chlorimipramine, or a bathing medium whose hi...

Journal: :Hypertension 1983
P Weidmann A Gerber R Mordasini

Several drugs used for standard antihypertensive therapy may also interact with the lipoprotein metabolism. The following has been observed after 1 to 12 months of treatment. Various thiazide-type diuretics may significantly increase the potentially atherogenic serum low-density-lipoprotein cholesterol (LDL-C) and/or very-LDL-C-fractions, while the antiatherogenic high-density-lipoprotein chole...

Journal: :Anesthesiology 2005
Astrid G Stucke Edward J Zuperku Viseslav Tonkovic-Capin Mirko Krolo Francis A Hopp John P Kampine Eckehard A E Stuth

BACKGROUND Inspiratory bulbospinal neurons in the caudal ventral medulla are premotor neurons that drive motoneurons, which innervate pump muscles such as the diaphragm and external intercostals. Excitatory drive to these neurons is mediated by N-methyl-d-aspartate (NMDA) receptors and alpha-amino-3-hydroxy-5-methylisoxazole-4-propionate (AMPA) receptors and is modulated by an inhibitory gamma-...

Journal: :The Journal of neuroscience : the official journal of the Society for Neuroscience 2012
Haruyuki Kamiya

Postsynaptic expression of AMPA-type glutamate receptors (AMPAR) is more mobile than previously thought. Much evidence suggests that AMPAR are delivered from intracellular reserved pools to postsynaptic sites in a constitutive, as well as activity-dependent manner by exocytosis, lateral diffusion, or diffusional trapping. These notions were supported by optical monitoring of AMPAR subunits labe...

Journal: :Journal of neurophysiology 2014
Tim D Ostrowski Daniela Ostrowski Eileen M Hasser David D Kline

Serotonin (5-HT), and its 5-HT1A receptor (5-HT1AR) subtype, is a powerful modulator of the cardiorespiratory system and its sensory reflexes. The nucleus tractus solitarii (nTS) serves as the first central station for visceral afferent integration and is critical for cardiorespiratory reflex responses. However, the physiological and synaptic role of 5-HT1ARs in the nTS is relatively unknown. I...

Journal: :The Journal of General Physiology 1983
L Kass P H Hartline A R Adolph

We investigated the action of LSD at the putative indoleaminergic lateral inhibitory synapse in the lateral eye of Limulus polyphemus. We recorded extracellular and intracellular voltage responses from eccentric cells while producing inhibition either by light or by antidromic stimulation of the optic nerve in the presence of LSD, serotonin (5-HT), chlorimipramine, or a bathing medium whose hig...

Journal: :Anesthesiology 2003
Astrid G Stucke Edward J Zuperku Viseslav Tonkovic-Capin Mislav Tonkovic-Capin Francis A Hopp John P Kampine Eckehard A E Stuth

BACKGROUND Inspiratory bulbospinal neurons in the caudal ventral medulla are premotor neurons that drive phrenic motoneurons and ultimately the diaphragm. Excitatory drive to these neurons is mediated by N-methyl-d-aspartate (NMDA) receptors and alpha-amino-3-hydroxy-5-methylisoxazole-4-propionate (AMPA) receptors and modulated by an inhibitory gamma-aminobutyric acid(A) (GABA(A))ergic input. T...

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