The objective of this study was to establish a validated stability-indicating LC method for routine analysis of amoxicillin trihydrate in bulk drug samples, different pharmaceutical formulations, and degradation kinetics of the drug under different ICH recommended stress conditions. Chromatographic separation was achieved by a Capacel Pak C18 column with 50:50% v/v methanol-0.02 M phosphate buf...

Refractive indices for the crystals potassium dihydgrogen phosphate, potassium titanyl phosphate and potassium niobate are measured. Samples of KDP from different crystal growers had slightly different refractive indices. The refractive indices of KDP for ordinary rays are studied as a function of temperature. The temperature coefficient of the refractive indices has little dependence on the wa...

Although numerous linear motifs that direct protein trafficking within cells have been identified, there are few examples of linear sorting signals mediating directed export of membrane proteins from the Golgi complex to the plasma membrane. The reovirus fusion-associated small transmembrane proteins are simple, single-pass transmembrane proteins that traffic through the endoplasmic reticulum-G...

1. The transport of sodium by frog skin and the maintenance of normal potassium levels within the cells of the skin are both dependent on metabolism and on a supply of phosphate bond energy. 2. Except for the common requirement of phosphate bond energy, the transfer mechanism for sodium and the mechanism for maintaining intracellular potassium appear to be independent. 3. The xanthines specific...

BACKGROUND Oral sodium phosphate is currently used for colon preparation prior to colonoscopy or barium enema. Sodium phosphate induces hyperphosphatemia, hypocalcemia, and hypokalemia. Elderly patients are at an increased risk for phosphate intoxication due to decreased glomerular filtration rate, medication use, and systemic and gastrointestinal diseases. We investigated these electrolyte dis...

From the Research Division, J. T. Baker Chemical Co., Phillipsburg, N. J. 08865. 1 Paper IV in the series “The Practical Analysis of High-Purity Chemicals.” Presented at the 22nd National Meeting of the AACC, Buffalo, N.Y., July 1970. Received April22, 1971; accepted June 3, 1971. Calcium carbonate Lithium carbonate Magnesium acetate Potassium chloride Potassium monobasic phosphate Sodium chlor...

Cefixime trihydrate is a broad spectrum cephalosporin antibiotic, effective against gram-positive and gram-negative bacterial infections. Simple and rapid method has been developed for the determination of cefixime trihydrate in bulk and pharmaceutical formulations. This method was based on the formation of bluish-green ion-pair complex of cefixime trihydrate with bromophenol blue in dimethyl s...

A simple and sensitive UV spectrophotometric method was developed and validated for the simultaneous determination of Potassium Clavulanate (PC) and Amoxicillin Trihydrate (AT) in bulk, pharmaceutical formulations and in human urine samples. The method was linear in the range of 0.2-8.5 μg/ml for PC and 6.4-33.6 μg/ml for AT. The absorbance was measured at 205 and 271 nm for PC and AT respectiv...

The objective of this study was to compare the use of thermal combustion (CNS) and inductively coupled plasma (ICP) to measure the total S content in plant-, animal-, and mineral-based feedstuffs, and to provide concentrations of other macro- and micro-minerals contained in these feedstuffs. Forty-five feedstuffs (464 total samples) were obtained from suppliers as well as swine feed and pet foo...

OBJECTIVE To investigate the in vitro effects of the antibacterial drugs, meropenem trihydrate, piperacillin sodium, and cefoperazone sodium, on the activity of human serum paraoxonase (hPON1). METHODS hPON1 was purified from human serum using simple chromatographic methods, including DEAE-Sephadex anion exchange and Sephadex G-200 gel filtration chromatography. RESULTS The three antibacter...