Somatostatin (SS) and noradrenaline (NA) are distributed in the rat cerebral cortex, and seizure activity is one of the aspects of behavior affected by both neurotransmitters. Due to the possible interaction between both neurotransmitter systems, we studied whether phenylphrine, an alpha 1-adrenoceptor agonist, and prazosin, an alpha 1-adrenoceptor antagonist, can modulate SS-like immunoreactiv...

Masuki, Shizue, Frank A. Dinenno, Michael J. Joyner, and John H. Eisenach. Selective 2-adrenergic properties of dexmedetomidine over clonidine in the human forearm. J Appl Physiol 99: 587–592, 2005. First published March 31, 2005; doi:10.1152/japplphysiol.00147.2005.— We tested the hypothesis that dexmedetomidine (Dex) has greater 2vs. 1 selectivity than clonidine and causes more 2-selective va...

Clonidine is a medication used to treat high blood pressure, attention deficit hyperactivity sleep disorders, and hyperarousal caused by post-traumatic stress disorder,. . Jump up ^ "Clonidine and Guanfacine IR vs ER: Old Drugs With "New" of CNS noradrenergic activity in PTSD: the case for clonidine and prazosin.". Sep 17, 2013 . The FDA has only approved two SRIs for the treatment of PTSD: ser...

Figure 1 Comparing systolic blood pressure (SBP), diastolic blood pressure (DBP), and mean arterial pressure (MAP) at baseline (figure on left) to development of autonomic dysreflexia during ejaculation with penile vibrostimulation (figure on right), after either placebo or prazosin was administered. The increase in SBP was mitigated during ejaculation when prazosin was administered compared to...

Isolated superfused rat atria release [H]acetylcholine when depolarized with 57 mM potassium. The depolarization-induced overflow of [H]acetylcholine is markedly inhibited by micromolar concentrations of epinephrine and norepinephrine. The a,-selective adrenergic agonist methoxamine also inhibits tritium overflow, but the «2-selective adrenergic agonist clonidine and the 0-adrenergic agonist is...

we investigated the a,-adrenoceptor subtypes of rabbit saphenous vein which has a mixed functional population of α1 and α2 -adrenoceptors. lateral saphenous veins were obtained from male rabbits weighing 3.20-4 kg, which were killed by overdose with pentobarbitone sodium (i.v. injection). they were easily dissected out and placed in cold, oxygenated modified krebs-henselite solution (krebs). ea...

Effect of penetration enhancers were studied on the permeation of antihypertensive drugs prazosin hydrochloride and atenolol through full thickness skin of swiss albino mice. Atenolol was delivered to skin from saturated alcoholic solution containing 5% of 1-decanol and alcohol alone, while prazosin hydrochloride was saturated in dimethyl formamide(DMF, 5% v/v in water) and dimethyl sulfoxide(D...