The predictive value of anti-Müllerian hormone (AMH) in Chinese women undergoing in vitro fertilization (IVF) treatment is data deficient. To determine the attributes of AMH in IVF, oocyte yield, cycle cancellation, and pregnancy outcomes were analyzed. All patients initiating their first IVF cycle with gonadotropin-releasing hormone agonist treatment in our center from October 2013 through Dec...

BACKGROUND Cardiovascular disease is associated with major morbidity and mortality in women in the Western world. Prediction of an individual cardiovascular disease risk in young women is difficult. It is known that women with hypertensive pregnancy complications have an increased risk for developing cardiovascular disease in later life and pregnancy might be used as a cardiovascular stress tes...

BACKGROUND We compared the performance of each of three tests for predicting pregnancy failure in the pregnancy of unknown (PUL) population. METHODS In a prospective observational study, we compared the performance of three models for the prediction of pregnancy failure in women with a PUL: (i) logistic-regression model incorporating vaginal bleeding, endometrial thickness (ET), initial serum...

The unmet medical need of providing evidence-based pharmacotherapy for pregnant women is recognized by the regulatory bodies. Physiologically based pharmacokinetic (PBPK) modeling offers an attractive platform to quantify anticipated changes in the pharmacokinetics (PKs) of drugs during pregnancy. Recent publications applying a pregnancy PBPK module to the prediction of maternal and fetal expos...

OBJECTIVE To develop a prediction model for term infants born large for gestational age (LGA) by customised birthweight centiles. METHODS International prospective cohort of nulliparous women with singleton pregnancy recruited to the Screening for Pregnancy Endpoints (SCOPE) study. LGA was defined as birthweight above the 90th customised centile, including adjustment for parity, ethnicity, ma...

failure to respond adequately to standard protocols and to recruit adequate follicles is called ‘poor response’. this results in decreased oocyte production, cycle cancellation and, overall, is associated with a significantly diminished probability of pregnancy. it has been shown that ovarian reserve tests, such as basal fsh, antimullarian hormone (amh), inhibin b, basal estradiol, antral folli...

We evaluated the use of multiplex antibody array methodology for simultaneous measurement of serum protein markers for first trimester screening of Down Syndrome (DS) and other pregnancy outcomes such as preeclampsia. For this purpose, we constructed an antibody array for indirect ("sandwich") measurement of seven serum proteins: pregnancy-associated plasma protein-A (PAPP-A), free beta subunit...

background: the aim of this study was to evaluate the relationship between ultrasonographic findings and serum progesterone and cancer antigen-125 (ca-125) levels in threatened miscarriage and to predict pregnancy outcome. materials and methods: in a prospective comparative case-control study, serum ca-125 and progesterone levels were measured for 100 pregnant women with threatened miscarriage ...