Objective :To determinate COVID-19 pandemic process effect on the increase of Precocious Puberty and Premature Thelarche Material Methods: Total 60 girls, younger than 8 years old, who complaint with breast development. Medical history physical examination findings, bone age, free T4, TSH, FSH, LH, estradiol levels patients were recorded in their first visits. According to LHRH test results div...

Despite standard clinical definitions and availability of diagnostic tests for precocious puberty, an intensive and structured investigation is needed in order to diagnose the aetiology in particular cases. A 4-year-old, phenotypically female child was referred to paediatric endocrinology consultation for premature pubarche and thelarche. There was an acceleration of growth velocity with high l...

Granulosa cell tumors (GCTs) are tumors that arise from granulosa cells, occurring in women 50 to 55 years of age but may occur at any age whereas Juvenile granulosa cell tumors usually occur in children and adolescents. A three years old girl with breast development but without any significant past medical history was referred to the Pediatric Clinic in Children hospital(University of Medical ...

OBJECTIVE To find out the diagnostic role of kisspeptin and neurokinin B in idiopathic central precocious puberty (ICPP) and premature thelarche (PT). METHODS The girls who presented with early breast development before the age of 8 years were evaluated. Patients with intracranial pathologies were excluded. Basal and stimulated follicle-stimulating hormone/luteinizing hormone (LH) levels and ...

OBJECTIVE To compare clinical signs of puberty onset in daughters of pre-eclampsia and normotensive pregnancies. DESIGN Population based follow-up study. METHODS In a cohort of 120 daughters of pre-eclampsia pregnancies and 203 daughters of pregnancies without pre-eclampsia, pubic hair growth and breast development were assessed at 11, 12 and 13 years of age by Tanner scores and by self-ass...

BACKGROUND Premature thelarche (PT) seems to be increasing and it is difficult to differentiate its early stages from precocious puberty (PP). Clinical and biochemical parameters are warranted to differentiate the two diagnoses. METHODS One hundred ninety-one girls aged 0.5-7 years were included. Diagnoses were validated and the girls were categorized to the groups PP (n = 27) and PT (n = 164...

OBJECTIVE To evaluate the clinical features of Chinese women with idiopathic hypogonadotropic hypogonadism (IHH). METHODS We retrospectively reviewed the clinical characteristics, laboratory and imaging findings, therapeutic management and fertility outcomes of 138 women with IHH. All patients had been treated and followed up at an academic medical centre during 1990-2016. RESULTS Among the...

Concerns about possible early pubertal development are a common cause for referral to pediatric medical subspecialists. Several recent studies have suggested that onset of breast and/or pubic hair development may be occurring earlier than in the past. Although there is a chance of finding pathology in girls with signs of puberty before 8 years of age and in boys before 9 years of age, the vast ...