Arsenic, cadmium and lead are well-known environmental contaminants, and their toxicity at low concentration is the target of scientific concern. In this study, we aimed to identify the potential effects of prenatal heavy metal exposure on the birth outcomes among the Myanmar population. This study is part of a birth-cohort study conducted with 419 pregnant women in the Ayeyarwady Division, Mya...

BACKGROUND Valproic acid (VPA) is used as a first-line antiepileptic agent and is undergoing clinical trials for use as a treatment for many disorders. Mothers undergoing VPA treatment during early pregnancy reportedly show increased rates of autism among their offspring. The benefits of curcumin supplementation were investigated using an animal model of VPA-induced autism. METHODS The study ...

Methylmercury (MeHg) is present in fish and a neurotoxicant at sufficiently high levels. One potential mechanism of MeHg toxicity early life epigenetic dysregulation that may affect long-term neurodevelopment. Altered DNA methylation nervous system-related genes has been associated with adult mental health outcomes. To assess associations between prenatal exposure (at the cytosine CG dinucleoti...

A 2002 analysis documented $54.9 billion in annual costs of environmentally mediated diseases in US children. However, few important changes in federal policy have been implemented to prevent exposures to toxic chemicals. We therefore updated and expanded the previous analysis and found that the costs of lead poisoning, prenatal methylmercury exposure, childhood cancer, asthma, intellectual dis...

extract when a woman undergoes genetic testing of her fetus, the physiologic and emotional demands are great. careful nursing assessment and support are vital. the main benefit of prenatal genetic diagnosis is that women be given the opportunity to coping with your pregnancy where fetal abnormalities has been diagnosed or achieve  to a complete relaxation with  the positive results obtained . e...

BACKGROUND & OBJECTIVES Administration of ex vivo-expanded human bone marrow-derived mesenchymal stromal cells (hBMMSC) obtained from single donors has shown therapeutic benefits in both preclinical and clinical studies. In this study, the safety, toxicity and biodistribution profiles of a pooled hBMMSC population, produced from three healthy donors were assessed in rodent and non-rodents. ME...

Toxicity testing in the 21st century is moving toward using high-throughput screening assays to rapidly test thousands of chemicals against hundreds of molecular targets and biological pathways, and to provide mechanistic information on chemical effects in human cells and small model organisms. First-generation predictive models for prenatal developmental toxicity have revealed a complex web of...

Antonelli, T., M. C. Tomasini, et al. (2005). "Prenatal Exposure to the CB1 Receptor Agonist WIN 55,212-2 Causes Learning Disruption Associated with Impaired Cortical NMDA Receptor Function and Emotional Reactivity Changes in Rat Offspring." Cereb Cortex. The aim of this study was to investigate whether prenatal exposure to the cannabinoid CB1 receptor agonist WIN 55,212-2 (WIN) at a daily dose...