wilson’s disease (wd) or hepato-lenticular degeneration is a rare autosomal-recessive disorder. a prevalence rate of 30 cases per million and a birth incidence rate of one per 30,000 to 40,000 are often quoted. in 40 to 50% of individuals with wd, hepatic dysfunction is the initial clinical manifestation. with the exception of liver transplantation, treatment of wd is only palliative and intend...

introduction: acute lymphoblastic leukemia (all) and non hodgkin’s lymphoma(nhl) are the most common cancers in childhood and  adolescence. most children with all and nhl have long term survival (>80%). endocrinopathy is a common complication in pediatric cancers following the treatment (20-50% prevalence), in addition, cytotoxic chemotherapy and radiotherapy can influence side effect on growth...

introduction: chronic liver disease and cirrhosis are the most important causes of growth failure, morbidity and mortality in children. cirrhosis consists of a variety of congenital, genetic, metabolic, and infectious causes in children. models for predicting of chronic liver disease severity, survival, and transplantation are useful for decision-making as well as medical interventions. the mos...

the present study aimed to investigate the effectiveness of group cognitive behavioral therapy in reducing anxiety and depression and glycemic control in children with type i diabetes. the study was quasi- experimental with a pre-test, post-test design with control group. for this purpose, 30 children with diabetes were selected from imam reza hospital in mashhad. the children were randomly ass...

stem cells are naïve or master cells. this means they can transform into special 200 cell types as needed by body, and each of these cells has just one function. stem cells are found in many parts of the human body, although some sources have richer concentrations than others. some excellent sources of stem cells, such as bone marrow, peripheral blood, cord blood, other tissue stem cells and hu...

recently, cell therapy has sparked a revolution in ischemic heart disease that will in the future help clinicians to cure patients. earlier investigations in animal models and clinical trials have suggested that positive paracrine effects such as neoangiogenesis and anti-apoptotic can improve myocardial function. in this regard the royan cell therapy center designed a few trials in collaboratio...

introduction:first, definition the stem cell refers to those cells that are still not clear and are not equipped for a particular task. these cells have proliferative properties and  ability to differentiate into other types of cells have become. this characteristic of stem cells to self-directed has absorbed professional opinion that extensive research is done in this regard. nowadays, stem ce...

liver failure, in an acute or chronic form, is a growing health problem ranking as one of the leading causes of death worldwide. inborn errors of metabolism characterized by defects in hepatic enzymes or other proteins with metabolic functions, such as receptors or transporters accompanied with environmental factors involve etiology and presentation of liver failure. currently, the only establi...

background currently, clinical endodontics includes procedures that are based on the ability of stem cells to accomplish repair (eg, direct pulp capping, apexogenesis, apexification, and even pulpal regeneration). an attempt is made to critically assess the current status in pulp regeneration therapy. methods: systematically, 2 distinctly different strategies exist involving stem cells for the ...

tissue-engineered biomaterials have existed approximately 40 years as simple biomimetic structures. replacement of human tissue with new tissue can be accomplished by generating replacements outside of the body or in situ in the body. in each case, the key elements are described as the tissue engineering triad of scaffolds, cells, and signals. scaffolds can be produced synthetically or derived ...