OBJECTIVE To evaluate the inflammatory pattern in maternal circulation, amniotic cavity, cervix and vagina from women with preterm prelabor rupture of membranes (PPROM) considering the occurrence of microbial invasion of the amniotic cavity (MIAC). METHODOLOGY A prospective study was performed in 58 women with PPROM before 34+0 weeks of gestational age. Twenty-six proteins were analyzed by a ...

prematurity is the most common cause of neonatal death. risk factors of premature birth can be related with ethnicity and genetic. there is no comprehensive high sample size study in kurdish ethnicity to determine risk factors related to prematurity. this study evaluated risk factors of preterm labor in kurdish ethnicity.this case-control study was conducted in 200 preterm infants (case group) ...

Male preterm infants are at greater risk of respiratory morbidity and mortality than females but mechanisms are poorly understood. Our objective was to identify the basis for the "male disadvantage" following preterm birth using an ovine model of preterm birth in which survival of females is greater than males. At 0.85 of term, fetal sheep underwent surgery (11 female, 10 male) for the implanta...

background: the aim of this study was to compare the biophysical profile parameters (bpp), especially amniotic fluid index (afi), before and after administration of corticosteroids (dexamethasone and betamethasone) and these two groups with each other. materials and methods: this double-blind clinical trial study was done on 70 patients for 28–34 weeks women having at least one preterm labor in...

OBJECTIVE Reliable semiquantitative assessment of histological placental acute inflammation is problematic, even among experts. Tissue samples in histology slides often show variability in the extent and location of neutrophil infiltrates. We sought to determine whether the variability in pathologists' scoring of neutrophil infiltrates in the placenta could be reduced by the use of 'regions of ...

Histologic chorioamnionitis occurs in approximately 50–60% of women with preterm premature rupture of membranes (PPROM). This condition is thought to represent antenatal inflammation/infection, which contributes to impending preterm birth and neonatal sepsis, chronic lung disease, and brain injury. Early and accurate diagnosis of chorioamnionitis is important, although it is limited by the fact...

Introduction. Intra-amniotic infection (IAI) is a major cause of preterm labor and adverse neonatal outcome. We evaluated amniotic fluid (AF) proteolytic cascade forming biomarkers in relation to microbial invasion of the amniotic cavity (MIAC) and IAI in preterm pregnancies with intact membranes. Material and Methods. Amniocentesis was made to 73 women with singleton pregnancies; 27 with suspe...

OBJECTIVE Previous studies reported that the clinical significance of intra-amniotic inflammation with a negative amniotic fluid (AF) culture is similar to that of intra-amniotic inflammation with microbiologically-proven AF infection. However, the magnitude of the fetal inflammatory response in these two conditions is different as gauged by umbilical cord C-reactive protein (CRP) concentration...

OBJECTIVE Preterm birth is associated with 5-18% of pregnancies and is the leading cause of neonatal morbidity and mortality. Amniotic fluid (AF) interleukin-6 (IL-6) is a key cytokine for the identification of intra-amniotic inflammation, and patients with an elevated AF IL-6 are at risk for impending preterm delivery. However, results of the conventional method of measurement (enzyme-linked i...

OBJECTIVE This study evaluated maternal C-reactive protein (CRP) as a predictor of microbial invasion of the amniotic cavity (MIAC) and histological chorioamnionitis (HCA) in women with preterm prelabor rupture of the membranes (PPROM) before and after 32 weeks of gestation. METHODS This study was a prospective observational cohort study of 386 women. Maternal serum CRP concentrations were ev...