A 26-year-old male patient presented to our rheumatology clinic with pain, swelling and limitation of movement in his right ankle, and also purpuric skin lesions in the lower extremity pretibial region. He was asked questions, and he said that he had been having chronic low back pain and morning stiffness for the last few years. His physical examination revealed that he had arthritis in his rig...

BACKGROUND Hyaluronidases are essential for the breakdown of hyaluronate (HA) in tissues and may be used to prevent the adverse effects of HA fillers. OBJECTIVES We explored the effect of hyaluronidase on exogenous and endogenous HA in vitro and in vivo. MATERIALS AND METHODS HA fillers were incubated with different concentrations of hyaluronidase and visualized by electrophoresis. HA fille...

The cutaneous manifestations of thyroid disease can be present in the hair, nails, and local or diffuse locations throughout the skin. Traditionally, thyroid-associated mucin deposition is present in a pretibial location on bilateral lower legs. We present a case of a growing plaque on the lower back of a 10-year-old girl, whose appearance coincided with a recent diagnosis of Hashimoto's thyroi...

Discussion | Periosteal ganglia are uncommon single or multiloculatedsubcutaneouscysticnodules.These lesionsare rarely encounteredbydermatologists and areusually seen in the orthopedic setting.Althoughdescribedmainly inmen, these lesions also have been reported1,2 in children. Periosteal ganglia typically involvethetibia,but reports2-4havealsodescribed involvementof themedialmalleolus, femur, i...

We present three young men who sustained closed diaphyseal fracture of the tibia and later developed severe osteocutaneous necrosis induced by heat during intramedullary reaming. They all had a narrow medullary cavity and in all a tourniquet had been used. Each developed a pretibial cutaneous blister soon after operation. In the following month severe osteomyelitis ensued, requiring segmental r...

Orbital and pretibial fibroblasts are targets of autoimmune attack in Graves' ophthalmopathy (GO) and pretibial dermopathy (PTD). The fibroblast autoantigen involved in these peripheral manifestations of Graves' disease and the reason for the association of GO and PTD with hyperthyroidism are unknown. RNA encoding the full-length extracellular domain of the TSH receptor has been demonstrated in...

A simple and safe technique is described for evacuation of pretibial haematoma in elderly patients. A Yankauer sucker attached to the wall suction is used to evacuate the haematoma under local anaesthesia. This technique is used in the accident and emergency department and the ward.