Background: Primary hypothyroidism is a common medical condition. It can lead to pituitary adenoma which is usually asymptomatic, but it can also lead to symptomatic macroadenomas which are hard to diagnose due to different clinical presentations. Case presentation: A 16-year-old girl presented for endocrinology consultation prior to neurosurgical operation. She had galactorrhea which was acco...

BACKGROUND While it is recognized that patients sometimes recover from autoimmune hypothyroidism, little is known about how rapidly this may occur. CASE REPORTS Two 13 year old girls had severe primary hypothyroidism (total T4 14.2 nmol/L with TSH 468 miU/L and total T4 7.7 nmol/L with TSH 183 miU/L) accompanied by goiter and positive thyroid peroxidase antibodies. There were delays in starti...

Pulmonary Hypertension To the Editor: We read with interest the excellent article on primary pulmonary hypertension (PPH) by Archer and Rich in the November 28, 2000, issue of Circulation.1 They did not mention, however, the association between hypothyroidism and PPH. Curnock et al2 have carried out a retrospective review of 41 patients with PPH. Of the 40 patients studied, 9 (22.5%) had eviden...

Twenty-seven patients with primary hypothyroidism were studied to evaluate the relationship between hepatic function and thyroid hormone deficiency in this disorder. In hypothyroidism, hypergammaglobulinemia was found in 71%, elevated glutamic oxaloacetic transaminase (GOT) in 48%, high lactic dehydrogenase (LDH) in 58%, hypercholesteremia in 52% and low elimination rate constant of indocyanin ...