Currently, there is still no effective therapy for neurodegenerative diseases (NDD) such as Alzheimer's disease (AD) and Parkinson's disease (PD) despite intensive research and on-going clinical trials. Collectively, these diseases account for the bulk of health care burden associated with age-related neurodegenerative disorders. There is therefore an urgent need to further research into the mo...

Mitochondrial DNA (mtDNA) somatic mutations or mutations in nuclear genes encoding mitochondrial proteins important for the assembly, activity, or maintenance of the individual oxidative phosphorylation (OXPHOS) complexes have been observed in tumors. Although the functional consequence of such mutations is unclear at the moment, retrograde signaling in response to OXPHOS defects can activate v...

conclusions the nps-induced ots may increase the pro-inflammatory responses. on the other hand, administration of antioxidants such as nac and vitamin c and e prior to exposure to metal nps significantly decreases ots conditions. evidence acquisition here, a nanotechnology approach is evaluated using nps in human neuronal protection against ots. it may be wide therapeutic applications in the ca...

BACKGROUND/AIMS Thalassaemia accompanied with iron-overload is common in Hong Kong. Iron-overload induced cardiomyopathy is the commonest cause of morbidity and mortality in patients with β-thalassaemia. Chronic iron-overload due to blood transfusion can cause cardiac failure. Decreased antioxidant defence and increased ROS production may lead to oxidative stress and cell injury. Iron-overload ...

Neurodegeneration with brain iron accumulation (NBIA) is a group of disorders characterized by dystonia, parkinsonism and spasticity. Iron accumulates in the basal ganglia and may be accompanied by Lewy bodies, axonal swellings and hyperphosphorylated tau depending on NBIA subtype. Mutations in 10 genes have been associated with NBIA that include Ceruloplasmin (Cp) and ferritin light chain (FTL...

in the present study, effects of iron excess treatments (0, 250, 500 mg l-1) were evaluated in four rice varieties including shafagh, khazar, hashemi and sadri in pot condition. afterward, effects of iron excess (10 and 250 mg l-1) were further investigated in the most resistant variety (shafagh) in sand culture with yoshida nutrient solution. this experiment was arranged as factorial in rcbd w...

Magnetic iron oxide nanoparticles (IONPs), for their intriguing properties, have attracted a great interest as they can be employed in many different biomedical applications. In this multidisciplinary study, we synthetized and characterized ultrafine 3 nm superparamagnetic water-dispersible nanoparticles. By a facile and inexpensive one-pot approach, nanoparticles were coated with a shell of si...

Oxidative precipitation is a facile synthesis method to obtain ferromagnetic iron oxide nanoparticles from ferrous salts—with unexplored potential. The concentration of base and oxidant alone strongly affects the particle's structure thus their magnetic properties despite same material, magnetite (Fe3O4), obtained when precipitated with potassium hydroxide (KOH) sulfate (FeSO4) treated nitrate ...

Increased production and use of nanomaterials has led to an ever growing exposure of living organisms tothese substances. Limited knowledge about possible toxicity of nanomaterials and their potential to harmliving creatures is becoming a serious concern. To address this problem, there is a need for development ofdiagnostic methods enabling effective determination of potential toxicity of nanom...

BACKGROUND Methamphetamine (METH), an abused illicit drug, disrupts many cellular processes, including energy metabolism, spermatogenesis, and maintenance of oxidative status. However, many components of the molecular underpinnings of METH toxicity have yet to be established. Network analyses of integrated proteomic, transcriptomic and metabolomic data are particularly well suited for identifyi...