It has recently emerged that the succinimide linkage of a maleimide thiol addition product is fragile, which is a major issue in fields where thiol functionalisation needs to be robust. Herein we deliver a strategy that generates selective cysteine thiol labelling reagents, which are stable to hydrolysis and thiol exchange.

PART A.GUIDELINES ON MANUFACTURING A.1. Definitions ...................................................................... A.2. General manufacturing recommendations .................................. A.3. Control of source materials ................................................... A.4. Control of vaccine production ................................................ A.5. Filling and containers...

OBJECTIVES Patterns of alcohol and cigarette use and abuse can be considered parallels due to their similar social, biological and epidemiological implications. Therefore, the cross-fertilization of policy research, including health warnings evidence, is justified. The objective of this study was to apply the lessons learned from the tobacco health warnings and plain packaging literature to an ...

BACKGROUND There is an ongoing debate regarding health-related on-pack information appearing on products with low nutritional quality. The purpose of the study was to contribute to this discussion by examining the relationship between health-related on-pack information and the overall nutritional value of highly processed ready-to-eat breakfast cereals (RTECs). METHODS Maximum variation sampl...

Background and aim Alcohol labelling enables people to make informed decisions about the products they purchase consume. This rapid review explores impact of health messaging product information on consumer attention, comprehension, recall, judgment behavioural compliance in relation alcohol use.Methods The adopted a multi-faceted search strategy identify primary studies and/or packaging, these...

N2-fixation by Rhizobium-legume symbionts is of major ecological and agricultural importance, responsible for producing a substantial fraction of the biosphere's nitrogen. On the basis of 15N-labelling studies, it had been generally accepted that ammonium is the sole secretion product of N2-fixation by the bacteroid and that the plant is responsible for assimilating it into amino acids. However...

The Ca(2+)-ATPase in the sarcoplasmic reticulum of skeletal muscle reacts with o-phthalaldehyde (OPA) to form a fluorescent isoindole product. The stoichiometry of labelling of the ATPase is 9 nmol of isoindole/mg of ATPase, corresponding to a 1:1 molar ratio of isoindole: ATPase. There is no evidence for any intermolecular cross-linking. Isoindole formation is faster in the presence of methyla...

Opposition to genetically modified food encompasses environmental concerns, food-safety concerns and ethical objections. Potential environmental benefits from transgenic crops are not well accepted. Genetic modification is a credence attribute that cannot be detected by consumers without labelling. In the absence of labelling a pooling equilibrium results in an adverse quality effect for those ...