Use of salivary progesterone for pregnancy diagnosis The concentration of steroid hormones in a female animal are an indicator of reproductive status. Progesterone enters the saliva via passive diffusion from the salivary glands. The level of progesterone present in the saliva of the horse and man can be used to diagnose pregnancy by use of an Enzyme-Linked Immunosorbent Assay [ELISA] (Smith, 2...

Fatty acid synthase (FAS), a nutritionally regulated lipogenic enzyme, is transcriptionally controlled by ADD1/SREBP1c (adipocyte determination and differentiation 1/sterol regulatory element-binding protein 1c), through insulin-mediated stimulation of ADD1/SREBP1c expression. Progesterone exerts lipogenic effects on adipocytes, and FAS is highly induced in breast tumor cell lines upon progeste...

OBJECTIVE This study was performed to assess the prognostic value of serum hCG, progesterone, and inhibin A levels measured at 11 days post-ET for predicting pregnancy outcome in women participating in IVF. METHODS Between May 2005 and April 2008, sera were obtained from 70 infertile women who underwent IVF-ET at 11 days post-ET and stored. HCG, progesterone, and inhibin A levels were measure...

What is EllaOne? EllaOne contains 30 mg ulipristal acetate (UPA), a synthetic selective progesterone receptor modulator, which has antagonistic and partial agonistic effects at the progesterone receptor level. Consequently, UPA should prevent the gene transcription normally activated by progesterone to produce the necessary proteins to support pregnancy. Over the last 10 years, other progestero...

BACKGROUND Although the MMP-2 promoter lacks a canonical progesterone response element (PRE), the hormone inhibits MMP-2 expression and is part of treatment protocols in gynecological invasive pathologies, including endometriosis and endometrial hyperplasia. This study aimed to explore the mechanism by which progesterone inhibits MMP-2 expression. METHODS The effect of progesterone on MMP-2 e...

Plasma concentrations of progesterone in non-pregnant female grey squirrels were never greater than 3.2 nmol/l and no significant differences were found between levels in anoestrous, pro-oestrous and oestrous animals. During pregnancy, plasma concentrations of progesterone increased significantly and reached a maximum level of 318 nmol/l at around day 35 of the 44 day period of gestation. After...

Contradictory findings show both positive and negative effect of progesterone on the premenstrual mood changes in women. Here we present the study investigating this relationship on the large sample of premenstrual women. 122 healthy, reproductive age women collected daily morning saliva samples and recorded intensity scores for the mood symptoms: irritability, anger, sadness, tearfulness, inso...

OBJECTIVE In this paper the relation between progesterone levels and embryotoxic effect of serum complement was studied. DESIGN The aim of this study was to validate hypothesis that progesterone is strong inhibitor of complement embryotoxic action. SETTING We used chick embryo like an experimental model for evidence of our hypothesis. We treated chick embryos by sera acquired from healthy p...

Serum testosterone, progesterone, luteinizing hormone, prolactin, and sex hormone-binding globulin levels were measured in 55 normal controls, in 31 patients with hyperplastic alterations of breast epithelium, and in 23 patients with breast cancer. All patients and controls were premenopausal, and they were comparable for age, weight, and body surface. In the controls, the mean level of testost...

Neurosteroids are steroids that are produced in the central nervous system (CNS). While progesterone and dehydroepiandostendione (the precursors of testosterone) are among the identified neurosteroids, it is not clear that testosterone could be considered as a neurosteroid. The testosterone synthesis has been demonstrated in the brain of castrated frog, but not in the rat brain. In the present ...