OBJECTIVE To evaluate the efficacy of progesterone and progestogens in the management of premenstrual syndrome. DESIGN Systematic review of published randomised, placebo controlled trials. STUDIES REVIEWED 10 trials of progesterone therapy (531 women) and four trials of progestogen therapy (378 women). MAIN OUTCOME MEASURES Proportion of women whose symptoms showed improvement with proges...

This study was aimed to investigate the bioequivalence of ibuprofen 125 mg suppository formulation (Ibukal®, test formulation from PT. Kalbe Farma, Tbk., Jakarta) and the ibuprofen suppository comparative formulation (Proris®, from PT. Pharos Indonesia, Jakarta) in 12 healthy volunteers. The pharmacokinetic parameters used in this study were the area under the concentration-time curve from time...

OBJECTIVE Randomized controlled trials (RCTs) have recently compared intramuscular 17α-hydroxyprogesterone caproate (17-OHPC) with vaginal progesterone for reducing the risk of spontaneous preterm birth (SPTB) in singleton gestations with prior SPTB. The aim of this systematic review and meta-analysis was to evaluate the efficacy of vaginal progesterone compared with 17-OHPC in prevention of SP...

Objective: To establish the quality standard for Penyankang Suppository. Method: Thin Layer Identification (TLC) was used for the qualitative identification of Caulis Sargentodoxae, Radix Salviae Miltiorrhizae, Rhizoma Corydalis and Rhizom Sparganii. High performance liquid chromatography (HPLC) was used to determine the contents of salvianolic acid B and tetrahydropalmatine. Results: Thin Laye...

The rectal route has proven its worth in terms of achieving successful drug delivery both locally and systematically. primary goal this invention was to develop evaluate Flax suppositories. To administer herbal powder internal sites, suppositories are placed directly into the rectum. A suppository comprises flax as a main active ingredient, administered through route, used laxative, treatment h...

OBJECTIVE We sought to provide evidence-based guidelines for using progestogens for the prevention of preterm birth (PTB). METHODS Relevant documents, in particular randomized trials, were identified using PubMed (US National Library of Medicine, 1983 through February 2012) publications, written in English, which evaluate the effectiveness of progestogens for prevention of PTB. Progestogens e...