نتایج جستجو برای: prognostic biomarkers
تعداد نتایج: 203607 فیلتر نتایج به سال:
AJA Biomarkers are any manifestation of a biological process, particularly in patients, that can be measured quantitatively. They can reflect either normal (physiologic) or disease (pathophysiologic) processes. Biomarkers are used in various contexts in prostate cancer. Prognostic biomarkers are related to the natural history of a disease over time, whereas predictive biomarkers are linked to t...
Improved understanding of cancer biology and advances in biotechnology bring us closer to the concept of personalized treatment of cancer. A key component of this new paradigm is development of biomarkers that can guide application of new and existing treatments. This requires a thorough understanding of the relationship between the biomarker and the treatment effect. Traditionally, most random...
Background: Prognostic biomarkers for cancer have the power to change the course of disease if they add value beyond known prognostic factors, if they can help shape treatment protocols, and if they are reliable. The aim of this study was to identify such biomarkers for colon cancer and to understand the molecular mechanisms leading to prognostic stratifications based on these biomarkers. Metho...
Heart failure has a high prevalence in developed countries. It is a frequent cause of hospital admission and has an important impact on morbidity, mortality and healthcare costs. Biomarkers have been widely studied in heart failure, as they improve diagnosis and prognostic assessment. Natriuretic peptides are already a part of daily clinical practice but several other biomarkers are being studi...
iomarkers are measurable cells, proteins, and/or metabolic yproducts that represent, either directly or indirectly, one or ore processes in a defined biological system or disease tate (2). Because biomarkers reflect health and disease ccording to genetic makeup, gene–gene interactions, gene– nvironmental interactions, and a dynamic interface beween genotype–phenotype relationships (3), one coul...
BACKGROUND Cutaneous melanoma is the deadliest skin cancer, with an increasing incidence and mortality rate. Currently, staging of patients with primary melanoma is performed using histological biomarkers such as tumor thickness and ulceration. As disruption of the epigenomic landscape is recognized as a widespread feature inherent in tumor development and progression, we aimed to identify nove...
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