Postoperative nausea and vomiting frequently complicate outpatient anesthesia and surgery. The duration of treatment for this complication must occasionally extend beyond discharge from the hospital. In this study, we evaluated the commonly used anti-emetic promethazine for its efficacy in the post-discharge period. Adult outpatient surgical patients who had excessive postoperative nausea and v...

Intramuscular (i.m.) injections of promethazine in 25 mg or 50 mg dosages are commonly used to treat space motion sickness in astronauts. The present study examined the effects of i.m. injections of promethazine on neuropsychological performance, mood states, and motion sickness tolerance in humans. Twelve men, mean age 36 _+3.1, participated in one training (no injections) and three treatment ...

Evidence is presented from more than 300 subjects to show that promethazine potentiates the action of six different narcotics (morphine, pethidine, oxymorphone, hydromorphone, fentanyl and pentazocine). In each instance there was prolongation rather than deepening of the narcotic action. Such an effect is consistent with the known membrane-stabilizing action of promethazine and is likely to occ...

Fifteen out of 18 "pink and puffing" patients completed a double-blind, placebo-controlled cross-over trial of diazepam and promethazine for breathlessness and reduced exercise tolerance. Dosages were 25 mg and 125 mg daily, respectively, and each course lasted two weeks. Patients with psychiatric or other major medical histories were excluded. Of the three patients who did not complete the tri...

OBJECTIVE The aim of this study was to describe the clinical effects of promethazine in overdose and explore the relationship between delirium and possible predictor variables. METHODS A case series of promethazine poisonings was identified from a prospective database of poisoning admissions to a regional toxicology service. Data were extracted including demographics, details of ingestion, cl...

A facile approach for the enantiomeric excess determination of enantiomeric mixtures without the necessity of pure enantiomer standards is presented. Promethazine and trimeprazine commercial nonracemic mixtures were used as cases study to probe the validity of the method. Chromatographic resolutions obtained with a chiral column AGP in reverse phase mode were 1.32-1.16 (promethazine) and 1.20-0...

children undergoing general anesthesia for strabismus surgery have a higher incidence of postoperative vomiting than those receiving the same anaesthesia for other types of ambulatory surgical procedures. droperidol (0/0 75 mg/kg iv) and promethazine (0.05-1.0 mg/kg) were used in 100 children between 2-15 years old. promethazine which has sedative property, anticholinergic antihistaminic, antie...

Accepted on 10 February 2014 _____________________________________________________________________________ ABSTRACT Promethazine HCl was oxidized electrochemically in presence of platinum electrodes as cathode and anode. The rate constant for the formation of the oxidized compound was calculated by first order plot. The rate of formation of oxidized compound increases with increase in concentra...

BACKGROUND The pharmacological management of violence in people with psychiatric disorders is under-researched. AIMS To compare interventions commonly used for controlling agitation or violence in people with serious psychiatric disorders. METHOD We randomised 200 people to receive intramuscular lorazepam (4 mg) or intramuscular haloperidol (10 mg) plus promethazine (25-50 mg mix). RESULT...

Background: Postoperative nausea and vomiting is a high unpleasant symptom in surgical procedures. This study compares the effectiveness of midazolam with promethazine as multipurpose drug in postoperative nausea and vomiting as a preoperative and anesthetic medication after appendectomy. Methods: This randomized, double – blind clinical trial study was performed in patients who underwent appen...