A recent study has provided evidence that the use of contralateral prophylactic mastectomy (CPM) is increasing.[1] Over the 5-year period from 1998 to 2003, the CPM rate doubled. Prior studies have shown that the surgical procedures chosen by patients are most commonly influenced by physician and surgeon recommendation. This has been observed in the choice of CPM as well.[2] The data strongly s...

BRCA mutation carriers have a life-long breast cancer risk between 55 and 85% and a high risk of developing breast cancer at a very young age, depending on the type of mutation. The risk of developing contralateral breast cancer after a first breast cancer is elevated up to 65%, especially in case of BRCA1 mutation and young age at the first breast cancer. Since bilateral prophylactic mastectom...

The effect of free muramyl tripeptide phosphatidylethanolamide (MTPPE) and liposome-encapsulated MTPPE (LE-MTPPE) on Klebsiella pneumoniae septicemia resulting from intraperitoneal bacterial inoculation was investigated in mice. When administering a single prophylactic dose at 24 h before bacterial inoculation, the percentage survival was 55% (MTPPE) or 40% (LE-MTPPE), whereas untreated control...

Background & Aims: Since apoptotic cell death plays a crucial role in many neurodegenerative diseases, control of apoptosis can be taken into account as a putative neuroprotective strategy. Due to the reported neuroprotective effect of the herbal medicine Nepeta Menthoides (Ostokhodus) on the axotomy-induced apoptosis in the spinal motoneurons, in the present study we have investigated its prop...

BACKGROUND Prophylactic antipyretic administration decreases the post-vaccination adverse reactions. Recent study finds that they may also decrease the antibody responses to several vaccine antigens. This systematic review aimed to assess the evidence for a relationship between prophylactic antipyretic administration, post-vaccination adverse events, and antibody response in children. METHODS...

The goal of the study was to compare the effectiveness of different suicide prevention measures implemented on bridges and other high structures in Switzerland. A national survey identified all jumping hotspots that have been secured in Switzerland; of the 15 that could be included in this study, 11 were secured by vertical barriers and 4 were secured by low-hanging horizontal safety nets. The ...

OBJECTIVES This study examined long-term response to an individual preventive intervention for high-risk college drinkers relative to the natural history of college drinking. METHODS A single-session, individualized preventive intervention was evaluated within a randomized controlled trial with college freshmen who reported drinking heavily while in high school. An additional group randomly s...

AIM To assess the extent to which a multivariate approach to modeling interrelated hematological indices provides more informative results than the traditional approach of modeling each index separately. MATERIALS & METHODS The effects of demographics and lifestyle on ten hematological indices collected from a Dutch population-based sample (n = 3278) were studied, jointly using multivariate d...

background: treating a chronic disease such as hemophilia is to improve the symptoms and quality of life (qol) of the patients. this study aimed to study the quality of life among hemophilic children and compare the quality of life between patients receiving prophylactic or on demand treatments. materials and methods: in this descriptive-comparative study, we enrolled 60 patients from three mai...

introduction : conventional amphotericin b is one of the antifungal choices as prophylactic and empiric treatment against fungal infections in febrile neutropenic patients. however the time of initiation, dosing and monitoring of drug adverse effects must be justified to maximize the efficacy and minimize the toxicities of this antifungal agent. methods : we conducted a prospective observationa...