نتایج جستجو برای: propoxy

تعداد نتایج: 252  

2014
Hailan Li Jandi Kim Hoh-Gyu Hahn Jun Yun Hyo-Soon Jeong Hye-Young Yun Kwang Jin Baek Nyoun Soo Kwon Young Sil Min Kyoung-Chan Park Dong-Seok Kim

The purpose of this study is to characterize the effects of KHG26792 (3-(naphthalen-2-yl(propoxy) methyl)azetidine hydrochloride), a potential skin whitening agent, on melanin synthesis and identify the underlying mechanism of action. Our data showed that KHG26792 significantly reduced melanin synthesis in a dose-dependent manner. Additionally, KHG26792 downregulated microphthalmia-associated t...

Journal: :Drug metabolism and disposition: the biological fate of chemicals 2004
Mi-Sook Kim Sui Wang Zhongzhou Shen Christopher J Kochansky John R Strauss Ronald B Franklin Stella H Vincent

Genetically obese Zucker rats exhibit symptoms similar to those of obese patients with insulin-resistance or Type II diabetes; therefore, they have been used as a genetic model to study obesity, as well as a pharmacological model for the discovery of new drugs for the treatment of Type II diabetes and hyperlipidemia. In the present study, we compared the pharmacokinetics of two novel peroxisome...

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