In this paper, we propose a novel interconnection network called three-level hierarchical cubic network (3-HCN), which extends the construction of hierarchical cubic networks (HCN) and ooers many additional advantages. The 3-HCN (with diameter links) has diameter smaller than that of an n-cube of the same size and uses nodes of degree 1 3 n + 2. We develop eecient and elegant algorithms for rou...

HCN is the putative product of C-1 and amino moieties of 1-aminocyclopropane-1-carboxylic acid (ACC) during its conversion to ethylene. In apple (Malus sylvestrus Mill.) slices or auxin-treated mungbean (Vigna radiata L.) hypocotyls, which produced ethylene at high rates, the steady state concentration of HCN was found to be no higher than 0.2 micromolar, which was too low to inhibit respiratio...

Vemana S, Pandey S, Larsson HP. Intracellular Mg is a voltage-dependent pore blocker of HCN channels. Am J Physiol Cell Physiol 295: C557–C565, 2008. First published June 25, 2008; doi:10.1152/ajpcell.00154.2008.—Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels are activated by membrane hyperpolarization that creates time-dependent, inward rectifying currents, gated by the mov...

Aims. Our goal is to study molecular gas properties in nuclei and large scale outflows/winds from active galactic nuclei (AGNs) and starburst galaxies. Methods. We obtained high resolution (0. ′′25 to 0. ′′90) observations of HCN and HCO J = 3 → 2 of the ultraluminous QSO galaxy Mrk 231 with the IRAM Plateau de Bure Interferometer (PdBI). Results. We find luminous HCN and HCO J = 3 → 2 emission...

BACKGROUND The pacemaker current I(f) is present in atrial and ventricular myocytes. However, it remains controversial whether I(f) overexpression in diseased states might play a role for arrhythmogenesis, because first I(f) activation in whole-cell recordings hardly overlapped the diastolic voltage of working myocardium. METHODS AND RESULTS To obtain further insight into I(HCN) and I(f) prop...

kinetics of bacterial growth and protease production were monitored on a novel isolated moderately halophilic bacterium, salinivibrio sp. strain ms-7, and maximum growth and protease activity was achieved after 48 hours at 30°c and 180 rpm. to determine the effect of various carbon sources on protease production, glucose, lactose, sucrose and maltose were investigated and  maximum production of...

background: as a drug target and an antigenic agent, hiv-1 protease (hiv-1 pr) is at the center of attention for designing anti-aids inhibitors and diagnostic tests. in previous studies, the production of the recombinant protease has been faced with several difficulties; therefore, the aims of this study were the easy production, purification of the soluble form of protease in e. coli and inves...

Proteases are important industrial enzymes used in different areas of industry, mainly detergent, food and leather industries. In this study, novel alkaline protease-producing bacterium was isolated from Geinarje hot spring and examined for maximum protease activity to be utilized in washing-powder. The isolated bacterium was cultured in mineral salt medium including 2% Skim Milk. Proteolytic a...

human immunodeficiency virus type 1 (hiv-1) protease inhibitors comprise an important class of drugs used in hiv treatments. however, mutations of protease genes accelerated by low fidelity of reverse transcriptase yield drug resistant mutants of reduced affinities for the inhibitors. this problem is considered to be a serious barrier against hiv treatment for the foreseeable future. in this st...

HCN channels are the molecular subunits of native funny (f-) channels of cardiac pacemaker cells and neurons. Although funny channels were first functionally described in cardiac cells in the late 1970s, cloning of HCN channels, of which four subunits are known today (HCN1-4), had to wait some 20 years to be accomplished, which delayed the investigation of HCN-related channelopathies. In cardia...