Amino acid composition can be used to determine protein quality, by comparing with reference amino values. This research was conducted the aim evaluate and study of acids quality native chicken meat giving Indigofera zollingeriana powder (IP) turmeric phytobiotics (TP) as green feed. Treatment ration study: R0 = control (research without feed; R1 substitution 10% soybean meal IP + 2.5% TP; R2 1...

Sympathetic nerve activity increases in the heart during cardiac failure. Here, we hypothesized that 1 integrins play a protective role in chronic -adrenergic receptor–stimulated cardiac myocyte apoptosis and heart failure. L-isoproterenol (iso; 400 g/kg per hour) was infused in a group of wild-type (WT) and 1 integrin heterozygous knockout (hKO) mice. Left ventricular structural and functional...

Acyl glucuronides are intrinsically reactive metabolites of carboxylate drugs, capable of undergoing hydrolysis, intramolecular rearrangement (isomerization via acyl migration), and intermolecular transacylation reactions. Transacylation with nucleophilic groups located on protein molecules leads to covalent drug-protein adducts. Protein adducts can also form from the rearrangement isomers via ...

BACKGROUND Soy isoflavones have numerous biological properties that suggest that they may protect against colorectal cancer. Colorectal epithelial cell proliferation has been used extensively as an intermediate endpoint biomarker for colorectal neoplasia. OBJECTIVE We tested the hypothesis that supplementation with soy protein containing isoflavones decreases colorectal epithelial cell prolif...

Atrial interstitial fibrosis plays a dual role in inducing and maintaining atrial fibrillation (AF). Hypoxia-inducible factor-1α (HIF-1α) has been reported as closely associated with renal, liver and pulmonary fibrosis diseases. However, whether HIF-1α is involved in myocardial fibrosis, and the associations between HIF-1α, transforming growth factor-β1 (TGF-β1) and matrix metalloproteinase-9 (...

Many studies reported that air pollution particulate matter (PM) exposure was associated with myocardial infarction (MI). Acrolein representing the unsaturated aldehydes, the main component of PM, derives from the incomplete combustion of wood, plastic, fossil fuels and the main constitute of cigarette smoking. However, the effect of acrolein on MI remains not that clear. In the current study, ...

BACKGROUND Recent cell-based studies have found that cGMP synthesis and hydrolysis by phosphodiesterase (PDE) appear compartmentalized, with nitric oxide synthase-derived and/or PDE type 5 (PDE-5)-hydrolyzable cGMP undetected at the sarcolemmal membrane in contrast to cGMP stimulated by natriuretic peptide. In the present study, we determine the functional significance of such compartments with...

Objective. To determine plasma markers of oxidative stress during the second and third trimester of pregnancy in patients with gestational diabetes mellitus (GDM). Study Design. We conducted a prospective nested case-control study involving 400 pregnant women, 22 of whom developed GDM. As control group, 30 normal pregnant women were chosen randomly. Plasma samples were analyzed for 8-iso-prosta...

Background—Oxidative stress is involved in the pathophysiology of atherosclerosis, diabetes mellitus, hypertension, obesity, and cigarette smoking, all of these being risk factors for coronary heart disease (CHD). We tested the hypothesis that risk factors of CHD are associated with abundant systemic oxidative stress. Methods and Results—We conducted a case-control study with 93 CHD patients an...

A 60-day feeding trial was conducted to evaluate the potential of using poultry by-product meal (PBM) as a partial replacement for fish meal (FM) in the diets for juvenile sobaity. Six iso-nitrogenous and iso-lipidic diets were formulated to contain graded levels of PBM, at 0 (as control diet), 15, 25, 35, 45, and 55% of FM replacement. Each diet was fed to groups of 20 juvenile sobaity in trip...