نتایج جستجو برای: protein phosphorylation
تعداد نتایج: 1273592 فیلتر نتایج به سال:
Significance Mutations that activate LRRK2 protein kinase cause Parkinson's disease. phosphorylates a subset of Rab GTPases, in particular Rab8 and Rab10. We show here details related to the mechanism by which Rab10 phosphorylation blocks initiation cilia formation, fundamental information how pathogenic interferes with normal cell physiology.
• The molecular chaperone CCT has functions in addition to protein folding. oncogenic transcription factor STAT3 binds oligomer. is not an obligate folding substrate of CCT. Reduction levels leads enhanced phosphorylation MCF7 cells. Sequestration by may provide a means regulate phosphorylation. Chaperonin Containing Tailless complex polypeptide 1 (CCT) essential required for the abundant prote...
introduction: increased oxidative stress is widely accepted to be a factor in the development and progression of alzheimer’s disease. triazine derivatives possess a wide range of pharmacological activities including anti-oxidative and anti-in.ammatory actions. in this study, we aimed to investigate the possible protective effect of 3-thioethyl-5,6-dimethoxyphenyl-1,2,4-triazine (tedmt) on h2o2-...
Aging, as a major risk factor of memory deficiency, affects neural signaling pathways in hippocampus. In particular, age-dependent androgens deficiency causes cognitive impairments. Several enzymes like protein kinase C (PKC) are involved in memory deficiency. Indeed, PKC regulatory process mediates α-secretase activation to cleave APP in β-amyloid cascade and tau proteins phosphorylation mecha...
Objective(s): Cyclic AMP (adenosine monophosphate) response element-binding protein (CREB) and Brain-derived neurotrophic factor (BDNF) are reported to broadly involve in learning capacity and memory. BDNF exerts its functions via tropomyosin receptor kinase B (TrkB). BDNF transcription is regulated by stimulating CREB phosphorylation. The CREB-TrkB-BDNF pathway is rep...
ABSTRACT Background and Objectives: Exposure to ionizing radiation in modern societies is inevitable and can cause a variety of adverse health effects such as cancer and birth defects. Therefore, a reliable, repeatable and sensitive method is required for evaluation of radiation exposure. The aim of this study was to determine the amount of hist...
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