نتایج جستجو برای: protein tyrosine phosphatase non

تعداد نتایج: 2476159  

Journal: :Marine Drugs 2006

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Journal: :Atlas of Genetics and Cytogenetics in Oncology and Haematology 2012

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Journal: :Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2012
Takeshi Kanno Ayako Tsuchiya Tadashi Shimizu Akito Tanaka Tomoyuki Nishizaki

BACKGROUND/AIMS We have shown that indomethacin has the potential to activate Ca2+/ calmodulin-dependent protein kinase II (CaMKII), regardless of cyclooxygenase (COX) inhibition. To understand the underlying mechanism, the present study investigated the effect of indomethacin on protein phosphatases such as protein phosphatase 1 (PP1), protein phosphatase 2A (PP2A), and protein tyrosine phosph...

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Journal: :Journal of Investigative Dermatology 2001

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Journal: :Chem. Commun. 2010

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Journal: :Atlas of Genetics and Cytogenetics in Oncology and Haematology 2015

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Journal: :Atlas of Genetics and Cytogenetics in Oncology and Haematology 2013

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Journal: :Pain 2016

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Journal: :Journal of Biological Chemistry 2006

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Journal: :The Journal of biological chemistry 1994
K L Milarski A R Saltiel

To explore the role of the protein tyrosine phosphatase Syp in insulin signaling, a catalytically inert mutant Syp protein was expressed under an inducible promoter in cells transfected with the human insulin receptor. Expression of the mutant phosphatase significantly reduced the stimulation of mitogenesis by insulin, indicating that the mutation produced a dominant negative phenotype. Tyrosin...

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