A phospholipase inhibitor (WSG) has been purified from Withania somnifera using gel-filtration and ion-exchange chromatographies. The WSG is an acidic glycoprotein. Its molecular mass as determined by SDS-PAGE was 27kDa. It neutralized the enzyme activity and pharmacological properties such as cytotoxicity, edema, and myotoxicity of a multi-toxic Indian cobra venom phospholipase (NNXIa-PLA) but...

Withania somnifera (L.) Dunal is an important medicinal plant with many pharmaceutical and therapeutic uses ranging from immunomodulation to anticancer property. Field cultivation of W. somnifera is time consuming and it not able to meet current global demands. For commercial production of withanolides, field grown plant materials have generally been used but the quality and uniformity in the l...

The present study investigated the possible protective role of Withania somnifera (Linn.) Dunal (Solanaceae) root powder against bromobenzene-induced oxidative damage in rat liver mitochondria. Administration of bromobenzene (10 mmol/kg body weight) to rats resulted in increased levels of liver marker enzymes, lipid peroxidation, TNF-α, IL-1β and VEGF. There was also marked depletion in the lev...

Pharmacognosy Research,2023,15,1,01-12.DOI:10.5530/097484900286Published:December 2022Type:Review ArticleAuthors:Shreya Dhanaji Bhosale, R Galib, and P K Prajapati Author(s) affiliations:Shreya Bhosale*, Galib R, Department of Rasa Shastra Bhaishajya Kalpana, All India Institute Ayurveda, New Delhi, INDIA. Abstract:Introduction: Ashwagandha (Withania somnifera Linn. Dunal) is an important frequ...

l-Asparaginase (E.C. 3.5.1.1) is used as a therapeutic agent in the treatment of acute childhood lymphoblastic leukemia. It is found in a variety of organisms such as microbes, plants and mammals. In plants, l-asparaginase enzymes are required to catalyze the release of ammonia from asparagine, which is the main nitrogen-relocation molecule in these organisms. An Indian medicinal plant, Withani...

During April-June 2010, red two-spotted carmine spider mites Tetranychus urticae Koch (Trombidiformes: Tetranychidae) were found on aerial apical parts of Ashwagandha Withania somnifera (L.) Dunal (Solanales: Solanaceae) plants in the Amritsar District of Punjab Province in the North Indian plains. The mites fed on the leaves, making them shiny white in color, which gradually dried off and were...

Contents 1. Introduction 1.1 Neurodegenerative disease in perspective 1.2. Searching for symptoms in traditional medicine 1.3. Approaches to scientific investigation 1.4. Plants as a source of useful therapeutic agents in neurodegenerative diseases 2. Plants and their constituents from Ayurvedic medicine 2.1 Withania somnifera 2.2. Bacopa monniera 2.3. Centella asiatica 2.4. Mucuna pruriens 3. ...

The present investigation explores the possibilities of using the root and leaf extracts of an important plant Withania somnifera targeting DM and to examine their hypoglycaemic and hypolipidaemic effects on Streptozotocin-induced diabetic rats. Withania somnifera root extracts (WSREt) and leaf extracts (WSLEt) were orally administered daily to diabetic rats for eight weeks. After the treatment...