Ball-and-sockets and protrusions are specialized interlocking membrane domains between fiber cells of the avascular lenses in all species studied [1, 2]. Although both domains are similar in their shape, surface morphology and are highly enriched with aquaporin-0 water channel protein, our previous studies reveal that ball-and-sockets and protrusions possess important structural and functional ...

OBJECTIVE The aim of this study was to investigate the role of peroxiredoxin 1 (Prdx1) in the invasiveness of pancreatic ductal adenocarcinoma (PDAC) cells. METHODS Immunohistochemistry was used to determine overexpression of Prdx1 in human PDAC tissues. Immunoprecipitation and immunocytochemistry were used to determine the interaction and intracellular distribution of Prdx1 and a member of t...

Morphometric parameters are analyzed and systematized of parasitic nematodes the species Trichuris sylvilagi Tiner, 1950, obtained from Lepus europaeus (Pallas, 1778). The following suggested for exact identification female T. nematodes: sizes body, its anterior posterior parts, width body at connection esophagus intestine, specific location vesicular cuticular protrusions vulva. Five metric es...

We show that coupling between a fast and a slow relaxation time causes the spontaneous formation of protrusions in colloids made of cross-linked polymers. The volume of the protrusions can be controlled by adjusting the ratio between the relaxation times. This, in principle, results in particles with levels of anisotropy that can be made "to order".

Amoeboidal cell crawling on solid substrates is characterized by protrusions that seemingly appear randomly along the cell periphery and drive the cell forward. For many cell types, it is known that the protrusions result from polymerization of the actin cytoskeleton. However, little is known about how the formation of protrusions is triggered and whether the appearance of subsequent protrusion...

Pancreatic cancers are aggressive because they are highly invasive and highly metastatic; moreover, effective treatments for aggressive pancreatic cancers are lacking. Here, we report that IGF2BP3 promoted the invasiveness and metastasis of pancreatic cancers through locally translated IGF2BP3-bound transcripts. In neural cells, transcripts sorted into cytoplasmic RNA granules are transported t...

We used sub-micron metal rod decorated surfaces, 'nano-lawn' structures, as a substrate to study cell-to-cell and cell-to-surface interactions of primary murine astrocytes. These cells form thin membranous tubes with diameters of less than 100 nm and a length of several microns, which make contact to neighboring cells and the substrate during differentiation. While membrane protrusions grow on ...