BACKGROUND Tendinopathy is very common in the general population. There are increasing numbers of clinical studies referring to platelet-rich plasma (PRP) and platelet-poor plasma (PPP) as treatments for tendinopathy. PURPOSE To perform a meta-analysis of the outcomes of the PRP groups by preparation method and injection technique in tendinopathy. To determine the clinical effectiveness of th...

Tohidnezhad, M; Wruck, C.J.; Varoga, D; Lippross, S; Drescher, W; +Pufe, T + Department of Anatomy and Cell Biology, RWTH Aachen University, Wendlingweg 2, 52074 Aachen, Department of Trauma Surgery, UKSH Campus Kiel, Department of Orthopaedic Surgery, RWTH Aachen University [email protected] and [email protected] Introduction Open fractures of bone are often colonized by several bacteri...

Bone marrow concentrate (BMC), which is enriched in mononuclear cells (MNCs) and platelets, has recently attracted the attention of clinicians as a new optional means for bone engineering. We previously reported that the osteoinductive effect of bone morphogenetic protein-2 (BMP-2) could be enhanced synergistically by co-transplantation of peripheral blood (PB)-derived platelet-rich plasma (PRP...

Flavonoids, a group of polyphenolic natural compounds, represent an important source of antioxidants in the human diet [ 1,2]. Although the mechanism of action of flavonoids is not well understood, these compounds have been found to be inversely related to mortality from coronary heart disease[3]. Aggregation of platelet is fundamental to a wide range of physiological processes, i.e. in the eve...

Platelet-rich plasma (PRP) containing hepatocyte growth factor (HGF) and other growth factors are widely used in orthopaedic/sports medicine to repair injured tendons. While PRP treatment is reported to decrease pain in patients with tendon injury, the mechanism of this effect is not clear. Tendon pain is often associated with tendon inflammation, and HGF is known to protect tissues from inflam...

Intraplatelet phospho-VASP analysis is a commonly used approach for monitoring of anti-platelet therapy; however, testing of intraplatelet phospho-VASP expression needs a high level of experience and proficiency. The ability to recognize how the pre-analytical variations can change the results would be helpful for the interpretation of data from intraplatelet P-VASP analysis. The aim of this st...

Platelet degranulation allows the release of a large amount of soluble mediators, is an essential step for wound healing initiation, and stimulates clotting, and angiogenesis. The latter process is one of the most critical biological events observed during tissue repair, increasing the growth of blood vessels in the maturing wound. Angiogenesis requires the action of a variety of growth factors...

BACKGROUND Autologous platelet-rich plasma has attracted attention in various medical fields recently, including orthopedic, plastic, and dental surgeries and dermatology for its wound healing ability. Further, it has been used clinically in mesotherapy for skin rejuvenation. OBJECTIVE In this study, the effects of activated platelet-rich plasma (aPRP) and activated platelet-poor plasma (aPPP...