BACKGROUND Leukocyte-poor platelet-rich plasma (LP-PRP) is hypothesized to be more suitable for intra-articular injection than leukocyte-rich PRP (LR-PRP) in the treatment of knee osteoarthritis. PURPOSE To compare clinical outcomes and rates of adverse reactions between LP-PRP and LR-PRP for this application. STUDY DESIGN Meta-analysis. METHODS The MEDLINE, EMBASE, and Cochrane databases...

Platelet-rich plasma (PRP) containing autologous thrombocyte growth factors is applied in regenerative medicine, but the lack of an optimized PRP preparation protocol causes unstable therapeutic effects. The aim of this study was to optimize the PRP preparation method to obtain the largest amount of growth factors released and compare the effects of PRP from different preparation methods in res...

PURPOSE OF THE STUDY By the expression of several growth factors from activated thrombocytes, the application of Platelet Rich Plasma (PRP) stimulates angiogenesis and regeneration thus stimulating recovery through cell differentiation. This study aimed to evaluate the effects of PRP injection on patients who had undergone surgery for fracture and in whom delayed union or nonunion had been dete...

BACKGROUND Platelet-rich plasma (PRP) has shown to be a general stimulation for repair. Purpose To determine the effectiveness of PRP compared with corticosteroid injections in patients with chronic lateral epicondylitis. STUDY DESIGN Randomized controlled trial; Level of evidence, 1. PATIENTS The trial was conducted in 2 teaching hospitals in the Netherlands. One hundred patients with chro...

Platelet‑rich plasma (PRP) is a promising strategy for intervertebral disc degeneration (IDD). However, the short half‑life of growth factors released from PRP cannot continuously stimulate the degenerated discs. Thus, the present study hypothesized that the combined use of PRP and bone marrow‑derived mesenchymal stem cells (BMSCs) may repair the early degenerated discs in the long term for the...

BACKGROUND Platelet-rich plasma (PRP) is an autologous concentration of human platelets in plasma. In this paper, we aimed to investigate the effect of PRP on hair growth. METHODS Platelet-rich plasma and platelet-poor plasma were prepared by sterile centrifugation and injected into shaved dorsal skin of mice (n = 10). Saline injection was used in the control group. The length of randomly plu...

Background Platelet-rich plasma (PRP) has shown to be a general stimulation for repair. Purpose To determine the effectiveness of PRP compared with corticosteroid injections in patients with chronic lateral epicondylitis. Study Design Randomized controlled trial; Level of evidence, 1. Patients The trial was conducted in 2 teaching hospitals in the Netherlands. One hundred patients with chronic ...

OBJECTIVE Patellar tendinopathy affects a substantial proportion of athletes involved in jumping or kicking activities. Platelet rich plasma (PRP) injections may be a promising treatment used in conjunction with common traditional therapies. CLINICAL FEATURES Patellar tendinopathy is often the result of repetitive or excessive overload on the patellar tendon. Activity modification, cryotherap...

BACKGROUND Platelet-rich plasma (PRP) has been shown to be a general stimulation for repair and 1-year results showed promising success percentages. PURPOSE This trial was undertaken to determine the effectiveness of PRP compared with corticosteroid injections in patients with chronic lateral epicondylitis with a 2-year follow-up. STUDY DESIGN Randomized controlled trial; Level of evidence,...

Abstract Background Supraspinatus tendon is a part of the rotator cuff shoulder, partial or full-thickness tear can affect secondary to trauma repeated microtrauma. The aim present study evaluate efficacy platelet-rich plasma (PRP) injection in comparison physical therapy for treatment chronic supraspinatus tears. Results At beginning study, there were no significant differences between both gr...