OBJECTIVE Calcium antagonists are the only oral vasodilators shown to influence mortality in primary pulmonary hypertension, but the high doses required are often poorly tolerated. Amlodipine is a novel, relatively well tolerated, calcium antagonist. It has not been previously tested in humans with pulmonary hypertension. DESIGN Calcium antagonists are claimed to be of benefit in the 20-30% o...

Congenital pulmonary artery agenesis is a rare cardiovascular malformation, frequently oligosymptomatic,1,2 that can be complicated with unilateral pulmonary edema3 or pulmonary hypertension.1,2,4 We report the case of a patient with congenital pulmonary artery agenesis and pulmonary hypertension who developed unilateral pulmonary edema and discuss the role of sildenafil in pulmonary hypertensi...

Cardiac catheterization and angiocardiography studies are reported in two patients with syphilitic aortic aneurysms, both of which compromised the pulmonary circulation. In the first instance the right main pulmonary artery was compressed and pulmonary hypertension proximal to the compression resulted. In the second patient the aneurysm ruptured into the pulmonary artery producing an aortic-pul...

Chronic kidney disease (CKD) is a major health problem and closely linked with cardiovascular disease. Pulmonary hypertension (PH) considered common comorbidity in CKD patients. In all, 100 patients were included our study. Transthoracic echo Doppler study was performed to measure pulmonary artery systolic pressure based on tricuspid jet. The prevalence of PH 60%; severity had significant assoc...

Cardiac catheterization and angiocardiography studies are reported in two patients with syphilitic aortic aneurysms, both of which compromised the pulmonary circulation. In the first instance the right main pulmonary artery was compressed and pulmonary hypertension proximal to the compression resulted. In the second patient the aneurysm ruptured into the pulmonary artery producing an aortic-pul...

Cardiac catheterization and angiocardiography studies are reported in two patients with syphilitic aortic aneurysms, both of which compromised the pulmonary circulation. In the first instance the right main pulmonary artery was compressed and pulmonary hypertension proximal to the compression resulted. In the second patient the aneurysm ruptured into the pulmonary artery producing an aortic-pul...

Congenital pulmonary artery agenesis is a rare cardiovascular malformation, frequently oligosymptomatic,1,2 that can be complicated with unilateral pulmonary edema3 or pulmonary hypertension.1,2,4 We report the case of a patient with congenital pulmonary artery agenesis and pulmonary hypertension who developed unilateral pulmonary edema and discuss the role of sildenafil in pulmonary hypertensi...

We experienced the surgical repair of an extremely rare pulmonary artery dissection without pulmonary hypertension. The patient had multiple coronary-pulmonary artery fistulae, which presumably caused pulmonary artery dissection. The surgical treatment included the closure of the multiple coronary fistulae and the resection of the intimal flap in the main pulmonary artery. The patient recovered...

• The study of pulmonary hypertension has been limited by lack of suitable means for producing chronic pulmonary hypertension in animals. Attempts to produce pulmonary hypertension in adult dogs, cats, and sheep by means of pneumoneetomy, hyposia, unilateral pulmonary artery ligation,' and repeated embolization, have resulted in only transient and inconsistent rises in pulmonary arterial pressu...

BACKGROUND Monocrotaline has been widely used to establish an animal model of pulmonary hypertension. The molecular target underlying monocrotaline-induced pulmonary artery endothelial injury and pulmonary hypertension remains unknown. The extracellular calcium-sensing receptor (CaSR) and particularly its extracellular domain hold the potential structural basis for monocrotaline to bind. This s...