1 Isolated pulmonary arterial and vein strips from sensitized or non-sensitized chickens exhibited dose-dependent contractions to adrenaline greater than, noradrenaline greater than, 5-hydroxytryptamine greater than, histamine greater than, dopamine. Individual variability in the responsiveness of the vessels to agonists was marked. In general veins were 2 to 25 times more sensitive to agonists...

Effects of raloxifene have been documented in the systemic circulation. However, its impact on the pulmonary circulation is unclear. The present study investigated the role of gender, endothelial modulation, and Ca(2+) channel in relaxations evoked by raloxifene in rat pulmonary arteries and veins. Vascular responses were studied on isolated pulmonary blood vessels mounted in a myograph and con...

The most striking point brought out in this study is that as long as a definite pressure is maintained in either the pulmonary or bronchial circulations, the admixture of bloods is extremely limited. It is easily conceivable that more mixture occurs normally than under the conditions of the experiment, but there is no reason for considering this to be a large difference. If, however, in either ...

HYLAND, JOHN W., GEORGE T. SMITH, LOCKHART B. MCGUIRE, DONALD C. HARRISON, FLORENCE W. HAYNES, AND LEWIS DEXTER. Efect of selective embolisation of various sized pulmonary arteries in dogs. Am. J. Physiol. 204(4) : 6 I g-625. I g63.-Pulmonary embolism was produced in 30 closed-chest 8-kg dogs with polystyrene spheres, glass beads, or blood clots of precise graded size. The sizes matched selecti...

TO THE EDITOR: I congratulate and thank Ebenroth (3) and Liske and Aschner (5) for their interesting, informative, and wellwritten Point:Counterpoint article. The physiology in patients with single ventricle, the distribution of flow to the systemic and pulmonary circulations, which are in parallel, largely depends on the relative resistances in the respective vascular beds. The goal of preoper...

Figure 1. Geometric model of proximal pulmonary arteries in a pig superimposed with volume rendered anatomic data obtained using CE-MRA The pulmonary circulation serves the important role of evenly distributing blood throughout the lungs so that gas exchange can occur over as large a surface area as possible. Individuals with unilateral pulmonary stenosis, a narrowing of either the right pulmon...

"Distribution of blood flow in isolated lung; relation to vascular and alveolar pressures" by J. B. West, C. T. Dollery, and A. Naimark (J Appl Physiol 19: 713-724, 1964) is a classic paper, although it has not yet been included in the Essays on the American Physiological Society Classic Papers Project (http://www.the-aps.org/publications/classics/). This is the paper that originally described ...