Recently it has been established that y toxin of Tityus serrulatus scorpion venom has a very high affinity to Na channels and can be successfully used as a marker during their purification from excitable membranes (Barhanin et al. 1983 ; Grishin 1983). There has, however, been some controversy concerning the effects of the y toxin on properties of Na channels in different tissues. Thus, in neur...

PURPOSE As Doppler ultrasound has been proven to be an effective tool to predict and compress the optimal pulsing windows, we evaluated the effective dose and diagnostic accuracy of coronary CT angiography (CTA) incorporating Doppler-guided prospective electrocardiograph (ECG) gating, which presets pulsing windows according to Doppler analysis, in patients with a heart rate >65 bpm. MATERIALS...

Weak, pulsing electromagnetic fields can modify biological processes. The hypothesis that responses to such induced currents depend on pulse characteristics was evaluated by using transcription as the target process. Two pulses in clinical use, the repetitive single pulse and the repetitive pulse train, were tested. These pulses produced different results from each other and from controls when ...

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Transcriptional pulsing has been observed in both prokaryotes and eukaryotes and plays a crucial role in cell-to-cell variability of protein and mRNA numbers. An important issue is how the time constants associated with episodes of transcriptional bursting and mRNA and protein degradation rates lead to different cellular mRNA and protein distributions, starting from the transient regime leading...

States first emerged in several famous locations around the world: Egypt, Mesopotamia, Indus, Central America, and China. These are often labeled by anthropologists as the “pristine states,” with all states that later emerged by contact and emulation labeled “secondary states.” Contrary to what is often thought however, states did not rise in a smooth trajectory toward some peak of power. Inste...

With damage tolerance rivalling advanced engineering alloys and thermoplastic forming capabilities analogous to conventional plastics, metallic glasses are emerging as a modern engineering material. Here, we take advantage of their unique electrical and rheological properties along with the classic Lorentz force concept to demonstrate that electromagnetic coupling of electric current and a magn...

We propose a novel single-deoxynucleoside-based assay that is easy to perform and provides accurate values for the absolute length (in units of time) of each of the cell cycle stages (G1, S and G2/M). This flow-cytometric assay takes advantage of the excellent stoichiometric properties of azide-fluorochrome detection of DNA substituted with 5-ethynyl-2'-deoxyuridine (EdU). We show that by pulsi...