Peptide vaccines incorporating B- and T-cell epitopes have shown promise in the context of various cancers infections. These are relatively simple to manufacture, but more immunogenic formulations considered a priority. We developed tetrabranched derivatives for this purpose based on novel peptide welding technology (PWT). PWTs provide molecular scaffolds efficient synthesis ultrapure dendrimer...

Left ventricular (LV) hypertrophy and concentric remodeling have been defined by using a variety of indexation methods and partition values (PVs) for LV mass and relative wall thickness (RWT). The effects of these methods on the distribution of LV geometric patterns in hypertensive subjects remain unclear. Echocardiograms were obtained in 941 patients with stage I to III hypertension and LV hyp...

The moderation roles of empathy and perceived waiting time (PWT) on post-pandemic travel intentions have not as yet been investigated. This study 684 Chinese resident respondents elicited how CO...

A photoinjector based on a multi-cell plane wave transformer accelerating structure has been commissioned at the UCLA Department of Physics’ PEGASUS Laboratory. Design and construction of the novel structure have been previously reported [J. Rosenzweig, et al. PAC Proceedings 1997], and recent operation with a thermionic cathode is being presented at this conference [P. Frigola, et al. these pr...

the present study attempted to compare the structural and functional changes of left heart ventricle in female basketball players of khuzestan superior league (aged between 18 and 29) during regular training and long-term detraining. out of 30 female players, 15 subjects were assigned randomly to regular training group and 15 subjects to long-term detraining group. the structural and functional...

Cross-sectional echocardiographic measurements of normalized septal curvature (NSC), systolic anterior motion of the center of the left ventricular cavity (CAM), and the M mode ratio of left ventricular posterior wall epicardial motion (PEM) to posterior wall thickening (PWT) were made in eight normal subjects, 16 patients with right ventricular volume overload (RVVO) and five with pressure ove...

Experimental studies have suggested that electrocardiographic recognition of left ventricular hypertrophy depends on geometric relationships involving wall thickness and chamber size. To determine the clinical significance of these observations, we studied the effects of echocardiographic LV mass (LVM), posterior wall thickness (PWT), interventricular septal thickness (IVST) and internal dimens...

Neuropathic pain is a debilitating condition that is often resistant to common analgesics, such as opioids, but is sensitive to some antidepressants, an effect that seems to be mediated by spinal cord 5-HT3 receptors. Because the analgesic potential of monoamine oxidase-A (MAO-A) inhibitors is understudied, we evaluated the potential antinociceptive effect of the reversible MAO-A inhibitors moc...

Diagnostic and prognostic biomarkers of nerve injury and/or pain as well improved therapeutics are needed, both on the battlefield to treat injured Service Members in civilian sector. Our previous research indicates that there several differentially expressed (DE) extracellular vesicle-derived microRNAs (EV-miRNAs) isolated from rat plasma following spinal ligation (SNL). As such, EV-miRNAs hol...

Twenty-seven crosses of mice derived from three random-mating, unselected strains (SWO, J. PGH) with 16 matings/pureline or cross were cohabited continuously and monogamously for a 365-d reproduction period to evaluate lifetime reproductive performance of the parents. Data from 3,249 litters born (2,792 surviving to weaning) were analyzed to study the effects of parity (number of litters) and t...