In the course of investigating the blood pyruvic acid levels we examined, amongst others, comatose patients with renal failure due to chronic nephritis and found the level to be normal. This finding was in contrast with that of high blood pyruvic acid levels in patients in coma due to other causes, e.g., hepatic (Snell and Butt, 1941 ; Amatuzio and Nesbitt, 1950; Carfagno, De Horatius, and Schw...

In the course of investigating the blood pyruvic acid levels we examined, amongst others, comatose patients with renal failure due to chronic nephritis and found the level to be normal. This finding was in contrast with that of high blood pyruvic acid levels in patients in coma due to other causes, e.g., hepatic (Snell and Butt, 1941 ; Amatuzio and Nesbitt, 1950; Carfagno, De Horatius, and Schw...

Rats were given a single dose of toxaphene (120 mg/kg equilavent to 1/2 LD50) and sacrificed at 1, 5, and 15 days. No alterations of levels of pyruvic or lactic acid in blood plasma were observed. In a second experiment, rats were given 2.4 mg/kg daily and sacrificed at 1, 3, and 6 months, and again no alterations of pyruvic or lactic acid levels were found. It is concluded that observed altera...

THE results of in vitro work have led to the postulation of several possible paths of pyruvate removal in animal tissues; namely (1) the scheme of Toenniessen & Brinkmann [1930] whereby 2 mol. of pyruvic acid are reduced to form 1 mol. of succinic acid, and the latter is then converted,successively into fumaric, malic, oxaloacetic and 1 mol. of pyruvic acid, (2) the scheme of Krebs & Johnson [1...

The photochemistry of pyruvic acid has received a large attention due to its relevance atmospheric chemistry. Pyruvic is produced in the troposphere from both biogenic and anthropogenic sources prototypical model for family -dicarbonyls. What makes particularly interesting gas-phase perceptive expected decarboxylation upon sunlight absorption. exact photodynamics leading this release CO2 remain...

Condensation and cyclization of 5-hydroxy- 1,2,4- thiadiazol-2-yl hydrazine 1 with pyruvic acid, phenacyl bromide, propargyl bromide and ally1 bromide afforded compounds 2,5,7 3, 4 ,6 and 8 respectively, Reaction of 1 with epichforohydrine afforded 4-hydroxy-N-[5-hydroxy- 1 ,3,4-thiadiazoly1] pyrazolidine 9