Introduction: The production of large amounts reactive oxygen species in severe malarial infection is due to parasite invasion erythrocytes. Malaria resistance medication has left malaria-endemic countries with no alternate source medications but traditional medicine. One such plants utilized by healers Phyllanthus amarus. Therefore, this study aims at ascertaining the antiplasmodial and cytoto...

2. Soxhlation: Soxhlet extraction is only required where the desired compound has a limited solubility in the solvent, and the impurity is insoluble in that solvent. If the desired compound has a high solubility in a solvent then a simple filtration can be used to separate the compound from the insoluble substance [1]. In a conventional soxhlet system plant material is placed in thimble-holder,...

Diatoms consumed by Rio Grande silvery minnows (Hybognathus amarus) collected 104 years apart were used to deduce ecological requirements of this endangered species and to infer a possible cause of its decline based on environmental conditions in the Rio Grande. In 1874, foraged diatoms were largely motile, silt tolerant generalist and epipelic species (e.g. Navicula capitatoradiata, Navicula c...

Biochemical Changes in serum of male albino rats treated with aqueous leaf extract of Phyllanthus amarus were examined. 50mg/kg and 100mg/kg of the extracts were administered orally and once daily to group I and group II of test animals respectively for 28 days. The third group which served as control received distilled water only. On the 29 day, the rats which had been fasted overnight were di...

BACKGROUND Phyllanthus amarus (Schum & Thonn), a plant belonging to the family of Euphorbiaceae is used in Ivorian traditional medicine to treat cardiovascular disorders such as hypertension. However, although this plant has been described as a diuretic agent, the underlying mechanism remains unclear. Therefore, the aim of the present study was to investigate the mechanism action of diuretic ef...

In a preliminary study, carriers of hepatitis B virus were treated with a preparation of the plant Phyllanthus amarus for 30 days. 22 of 37 (59%) treated patients had lost hepatitis B surface antigen when tested 15-20 days after the end of the treatment compared with only 1 of 23 (4%) placebo-treated controls. Some subjects have been followed for up to 9 months. In no case has the surface antig...

The response surface methodology using the Box-Behnken design was established to describe supercritical carbon dioxide assisted extraction of phyllanthin from Phyllanthus amarus Schum and Thonn leaves prior to HPLC analysis. The effects of extraction pressure, temperature, modifier concentration and extraction time on the yield of phyllanthin were investigated. By solving the regression equatio...

Background: Recently, we have highlighted the immunomodulatory activity of the standardized extracts of Phyllanthus amarus and P. urinaria. The present study was carried out to correlate between the prevalent constituents of the herbs and their inhibitory effects on phagocytic activity of human neutrophils. Methods: The compounds, gallic acid, ellagic acid, corilagin, geraniin, phyllanthin and ...