N-[3-[[[(1S)-4-(5-Amino-2-pyridinyl)-1-[[4-difluoromethylene)-1-piperidinyl]carbonyl]butyl]amino]sulfonyl][1,1'-biphenyl]-2-yl]acetamide hydrochloride (SSR182289A) is a novel, potent, and selective thrombin inhibitor. We have examined the antithrombotic properties of SSR182289A administered by i.v. and p.o. routes in several different animal thrombosis models in comparison with reference antith...

In the isolated rabbit heart, it was shown that (1) manganese ions (Mn ) (2-4 ITIM) suppressed the activity of atrioventricular (AV) nodal cells located in the AN, N, and NH regions without preventing regenerative responses in atrial or His bundle fibers when these fibers were directly stimulated, (2) tetrodotoxin (TTX) in concentrations of 5 X 10" g/ml Tyrode's solution rendered atrial and His...

salinity is among important soil stresses adversely affecting the process of nitrogen (n) fixation in leguminous plants in different parts of the world. it has been indicated that salinity can inhibit the early stages of nodulation process between bacterium and the host plant including the exchange of signal molecules (nod gene inducers). there has not been any research regarding the effects of...

The electrophysiological properties of atrioventricular (AV) nodal dual pathways have traditionally been investigated with premature stimuli delivered with right atrial pacing. However, little is known about the functional characteristics of AV nodal inputs outside of this context. Superfused rabbit triangle of Koch preparations (n = 8) and Langendorff-perfused hearts (n = 10) were paced throug...

The anatomical atrioventricular node was first described by Tawara in 1906.1 Although some surmised the node to be the region responsible for delay between contraction of atria and ventricles, Erlanger in 1912 localized the major portion of delay to a latency at the transition between atrial and nodal fibers.2 Nearly a century of research on properties of the atrioventricular (AV) node has subs...

Congenital heart block (CHB) is a conduction abnormality characterized by complete atrioventricular (AV) block. CHB affects fetuses and/or newborn of mothers with autoantibodies reactive with ribonucleoproteins 48-kDa SSB/La, 52-kDa SSA/Ro, and 60-kDa SSA/Ro. We recently established animal models of CHB and reported, for the first time, significant sinus bradycardia preceding AV block. This une...

BACKGROUND The AV node is frequently the site of reentrant rhythms. These rhythms arise from a slow and a fast pathway for which the anatomic and functional substratum remain debated. This study proposes a new explanation for dual-pathway physiology in which the posterior nodal extension (PNE) provides the substratum for the slow pathway. METHODS AND RESULTS The anatomic and functional proper...

PURPOSE We have previously described a means to maintain bone allotransplant viability, without long-term immune modulation, replacing allogenic bone vasculature with autogenous vessels. A rabbit model for whole knee joint transplantation was developed and tested using the same methodology, initially as an autotransplant. MATERIALS/METHODS Knee joints of eight New Zealand White rabbits were e...

we discuss in this paper the strong convergence for weighted sums of negatively orthant dependent (nod) random variables by generalized gaussian techniques. as a corollary, a cesaro law of large numbers of i.i.d. random variables is extended in nod setting by generalized gaussian techniques.

OBJECTIVES Firstly, to compare effects of adenosine on membrane potential and refractoriness in AV nodal and atrial cells. Secondly, to assess the contribution of the effects of adenosine on IKAdo and ICaL to its effects on the functional electrophysiological properties in the two cell types. METHODS The whole cell patch clamp technique was used to record action potentials and ion currents in...