Rabies is a zoonotic virus that is extremely lethal to humans and many wildlife species such as raccoons, skunks, foxes, as well as domestic animals such as cats, dogs, and livestock. Reservoirs of the rabies virus throughout species specific populations pose an enormous risk of exposure and infection of domestic animals that have direct contact with humans. The most effective way to prevent wi...

OBJECTIVE To evaluate the effect of various routes of administration and number of doses of 3 commercially produced rabies vaccines on serum antibody responses and protection in mice challenged by intracerebral injection with fixed-strain rabies virus. ANIMALS 2,213 mice. PROCEDURE Inactivated, adjuvanted rabies vaccines were administered to mice in either 2, 1, or 0 (control) doses via IP,...

A method for obtaining large quantities of defective interfering (DI) rabies virus particles that fulfill all the criteria delineated by Huang and Baltimore (1970) is described. The purified rabies DI virion was found to be much shorter (60 to 80 nm) than the complete virion (180 nm) and to have a viral genome of about half the size of normal rabies RNA but with all of the structural proteins o...

Rabies has one of the highest case-fatality ratios of any infectious disease. This report provides recommendations for public health officials, veterinarians, animal control officials, and other parties engaged in rabies prevention and control activities and should serve as the basis for standardizing procedures among jurisdictions. The recommendations regarding domestic animal vaccination, man...

Rabies is an endemic infectious disease and one of the most important causes of human mortality in both underdeveloped and developing countries. In Turkey, 167,000 individuals are believed to be victims of animal bites annually. In this study, we investigated Turkish physicians' knowledge and clinical awareness of rabies caused by animal bites. This was a cross-sectional, analytical study. We u...

Since 2000, there has been a legal requirement in the UK that dogs and cats should have an effective rabies vaccination with demonstrable sero-conversion if their owners wish to avoid quarantine on re-entry to the UK. In 2002, 10,483 rabies titres were determined on dogs at the VLA. Statistical analyses assessed the efficacy of each vaccine within different dog breeds. Animal size, age, breed, ...

The International Conference in Kiev provided information on the valuable experience the re-emergence of rabies in some parts of Europe gained in the control and elimination of rabies and other significant animal diseases and zoonoses through the use of appropriate strategies and standardized recommended diagnostic and vaccines with a strong and close partnership among veterinary and public hea...