Background. Conventional management of thyrotoxicosis includes antithyroid drugs, radioactive iodine, and surgery while adjunctive treatment includes beta-blockers, corticosteroids, inorganic iodide and iopanoic acid. Very rarely, patients may be resistant to these modalities and require additional management. Case Presentation. A 50-year-old lady presented with weight loss and palpitations dia...

Well-differentiated thyroid carcinoma (WDTC) generally has a favorable prognosis. However, patients with distant metastatic disease experience progression of disease with a higher mortality. A subset of patients not previously described may challenge the conventional dogma regarding the progressive nature of all metastatic WDTC. Through analysis of our database, we identified patients with dist...

The splitting of atoms, also known as nuclear fission, produces radiation and radioactivity. Dr Lise Meitner discovered how radioactivity could be produced in 1939. She found that firing a small particle called neutron into another atom cause to released. Radioactive atoms created this way can useful for detecting cancer or checking whether the body’s organs are working properly. When radioacti...

The case records of 262 patients who received 131I therapy during a 6-year period were analysed retrospectively. These included seventy-eight patients who received more than one therapeutic dose. The major indication for 131I therapy was thyrotoxicosis occurring in patients aged 40 years and over. The racial incidence in this series is striking. The effects on thyroid function of two low-dose s...

There are limited treatment options for patients with radioactive iodine refractory, progressive differentiated thyroid cancer. Although there is consensus that multikinase inhibitor therapy should be considered in patients with progressive disease with considerable tumor load or symptomatic disease, uncertainty exists on the optimal timing to treat with a multikinase inhibitor, especially for ...

Radioactive iodine (RAI) therapy plays an important role in the management of thyroid malignancies. Leukemia is a very rare complication of radioactive therapy. There are very few case reports with doses below 100 mCi causing leukemia. We report a case of papillary carcinoma of the thyroid treated with 80 mCi RAI who later developed acute myeloid leukemia. Thus, all patients with thyroid carcin...

peritoneally or intrapleurally into mice or patients bearing cancerous effusions remains largely local ized in the cavity and therefore can be used suc cessfully for intracavitary tumor therapy. Later (3, 9, 10), similar intracavitary retention of radio active material, suggesting analogous therapeutic application, was obtained with particle suspen sions of radioactive chromic phosphate (CrP320...

Monocyte recognition of i mmunoprotei ncoated erythrocytes in vitro was studied in 21 patients with immune hemolytic anemia. Simultaneous assessment of immunoglobulin and complement components on the patients’ erythrocytes was performed. The patients were heterogeneous in relation to associated diseases, therapy, and duration of disease state; 15 were studied within 1 mo of diagnosis and 4 addi...

Monocyte recognition of immunoprotein-coated erythrocytes in vitro was studied in 21 patients with immune hemolytic anemia. Simultaneous assessment of immunoglobulin and complement components on the patients' erythrocytes was performed. The patients were heterogeneous in relation to associated diseases, therapy, and duration of disease state; 15 were studied within 1 mo of diagnosis and 4 addi...

IN THE euthyroid patient, rapid supraventricular tachyeardias occur and are often resistant to prophylactic treatment with quinidine or pronestyl.' In an attempt to evaluate the effect of radioactive iodine in cases of supraventricular tachycardia resistant to antiarrhythmnic drugs, the authors treated 25 such patients with radioactive iodine and observed them for periods up to 6 years.2 In all...