نتایج جستجو برای: radiochemical
تعداد نتایج: 1803 فیلتر نتایج به سال:
Tetrabenazine (TBZ), a high affinity and specific inhibitor of the vesicular monoamine transporter, has been labeled with carbon-l 1 as a potential probe for in viva positron emission tomographic imaging of monoaminergic neuronal losses in neurodegenerative diseases. [“CITBZ was synthesized by O-[“Clmethylation of the 9-0-desmethylTBZ using [“C]methyl iodide in the presence of tetrabutylammoniu...
A new approach to the synthesis of 2-fluoro-2-deoxy-d-glucose (FDG, [(19/18)F]-) is described, which employs supported perfluoroalkylsulfonate precursors , where the support consists of insoluble polystyrene resin beads. Treatment of these resins with [(19)F]fluoride ion afforded protected FDG [(19)F]- as the major product, and the identities of the main byproducts were determined. Acidic remov...
Microglial activation is commonly identified by elevated levels of the 18 kDa translocator protein (TSPO) in response to several inflammatory processes. [(11)C]PBR28 is one of the most promising PET tracers to image TSPO in both human and non-human primates. In this study, we optimized the radiolabeling procedure of [(11)C]PBR28 for higher radiochemical yield, radiochemical purity, and specific...
introduction: ubiquicidin 29-41 (ubi) is a fragment of the cationic antimicrobial peptide that is present in various species including humans. the purpose of this study was to investigate radiochemical and biological characteristics of [6-hydrazinopyridine-3-carboxylic acid (hynic)]-ubi 29-41 designed for the labeling with 99mtc using tricine as coligand. methods: synthesis was preformed on a ...
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