Radiopharmaceuticals are radioactive compounds that are prepared by a radiopharmasist and used in Nuclear Medicine departments for diagnostic or therapeutic purposes of human diseases. They are generally used i.v. so they have to be sterile and apyrogenic like other parenteral drugs. Effecting in a correct way and localising in the desired tissue with a sufficient amount, physicians and Nuclear...

122 patients who presented with or developed calcification within metastatic ovarian cancer. Changes in soft tissue lesion size and the development of calcification have been correlated with histopathology and outcome. The study group was compared with a control group of 1577 patients who had a CT scan performed at least once during follow-up. A positive relationship between calcification and t...

Medical application of ionizing radiation and radioactive isotopes were considered almost immediately after their discovery. The intense research interest in radioactivity, materials structure, subatomic particles and in the establishment of physical principles resulted in milestone inventions such as the radiotracer principle, particle accelerators, nuclear reactors and detectors sensitive eno...

1. The use of specific radiotracers called radiopharmaceuticals for imaging organ function and disease states is a unique capability of nuclear medicine. Unlike other imaging modalities such as Computed Tomography (CT), Magnetic Resonance Imaging (MRI) and Ultrasonography (US), nuclear medicine procedures are capable of mapping physiological function and metabolic activity and thereby giving mo...

PURPOSE This short review aims to cover the more recent and promising developments of carbon-11 (11C) labeling radiochemistry and its utility in the production of novel radiopharmaceuticals, with special emphasis on methods that have the greatest potential to be translated for clinical positron emission tomography (PET) imaging. METHODS A survey of the literature was undertaken to identify ar...

In the continuous search for earlier diagnosis and improved therapeutic modalities against cancer, based on our constantly increasing knowledge of cancer biology, aptamers hold the promise to expand on current antibody success, but overcoming some of the problems faced with antibodies as therapeutic or delivery agents in cancer. However, as the first aptamer reached the market as an inhibitor a...

In the last one and half decade, Lu has emerged as one of the most important and useful radionuclides for the development of a wide variety of targeted radiotherapy agents owing to its suitable nuclear decay characteristics, comparatively longer half-life and production feasibility using medium flux research reactors. Radiopharmaceuticals Division (RPhD), BARC has done pioneering work in the fi...

Patients undergoing nuclear medicine procedures for cancer therapy are administered radiopharmaceuticals that emit various types of radiation. Because radiation has differential delivery to and uptake by cells in tissue, radiation exposures are often highly nonuniform. Some cell populations in a tissue may contain widely different amounts of radioactivity, whereas other cell populations in the ...

Introduction In nuclear medicine, diagnostic imaging displays the metabolic function of the human body. The radiopharmaceuticals enable cancer imaging as unbound isotopes or simple compounds, non target tracers, target tracers and target cancer radiopharmaceuticals (1). Molecular imaging strategies of PET radiopharmaceuticals and combined technology of PET-CT have a major role in oncology today...